Results 111 to 120 of about 1,102,607 (331)
SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair
Nature Communications, 2015 XPC recognizes UV-induced DNA lesions and initiates their removal by nucleotide excision repair (NER). Damage recognition in NER is tightly controlled by ubiquitin and SUMO modifications.
L. van Cuijk +11 more
semanticscholar +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Nucleotide Excision Repair Schematic
, 2013 When DNA is damaged by sunlight, the damage is recognized differently depending on whether the DNA is transcriptionally active (transcription-coupled repair) or not (global excision repair). After the initial recognition step, the damage is repaired in a
Jill O Fuss (63030) +1 more
core +1 more source
Mechanism of Release and Fate of Excised Oligonucleotides during Nucleotide Excision Repair [PDF]
, 2012 A wide range of environmental and carcinogenic agents form bulky lesions on DNA that are removed from the human genome in the form of short, ∼30-nucleotide oligonucleotides by the process of nucleotide excision repair.
Sancar, Aziz +3 more
core +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source
Cells, 2020 LAP2-Emerin-MAN1 (LEM) domain-containing proteins represent an abundant group of inner nuclear membrane proteins involved in diverse nuclear functions, but their functional redundancies remain unclear.
Bernhard Moser +4 more
doaj +1 more source
Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability
Molecules and Cells, 2014 Summary R-loops, consisting of an RNA-DNA hybrid and displaced single-stranded DNA, are physiological structures that regulate various cellular processes occurring on chromatin.
J. Sollier +5 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta +7 more
wiley +1 more source
Chromatin structure and DNA damage repair
Epigenetics & Chromatin, 2008 The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks, single strand breaks, oxidative lesions and ...
Dinant Christoffel +2 more
doaj +1 more source
Nucleotide Excision Repair in Mammalian Cells [PDF]
Journal of Biological Chemistry, 1997 is found throughout thenatural world in organisms ranging from mycoplasma to mam-mals. In humans, NER is a major defense against the carcino-genic effects of ultraviolet light from the sun. This repair path-way acts with varying efficiencies on a wide variety of DNAalterations and is especially important for bulky, helix-distort-ing lesions.
openaire +2 more sources