Results 141 to 150 of about 127,063 (412)

Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins

FEBS Open Bio, EarlyView.
With the ultimate goal of understanding the association of toxin‐immunity modules to temperate phages, we characterized toxins from three prophages and examined cross‐protection from immunity proteins. The toxins exhibit adenosine 3′‐pyrophosphokinase activity and are toxic in Escherichia coli.
Eloïse M. Paulet, Julia Bartoli, Atakan Kabtan, Chloé M. Piras, Audrey C. Tempier, Eric Cascales, Julie P. Viala   +6 more
wiley   +1 more source

XAB2, a novel tetratricopeptide repeat protein, involved in transcription-coupled repair and transcription. [PDF]

, 2000
Nucleotide excision repair is a highly versatile DNA repair system responsible for elimination of a wide variety of lesions from the genome. It is comprised of two subpathways: transcription-coupled repair that accomplishes efficient removal of damage ...
Aboussekhra, Adams, Altschul, Araujo, Araujo, Bauren, Bohr, Bootsma, Carreau, Citterio, Das, de Cock, de Laat, Dix, Elisabetta Citterio, Friedberg, Goebl, Hanawalt, Henning, Hiroshi Asahina, Hwang, Jan H.J. Hoeijmakers, Jing-Ping Yeo, Kiyoji Tanaka, Lamb, Lamb, Li, Li, Marinoni, Masafumi Saijo, Matsuda, Mayne, McCracken, McDonald, Mellon, Min-Cheh Khaw, Misteli, Mu, Nagai, Nance, Naohiko Kodo, Neer, Selby, Selby, Selby, Shinya Kamiuchi, Sikorski, Sikorski, Sugasawa, Suzanne Rademakers, Tantin, Tantin, Toshiro Matsuda, Troelstra, Tzamarias, van der Voorn, van Gool, van Hoffen, van Hoffen, Venema, Venema, Wim Vermeulen, Winzeler, Yoshimichi Nakatsu   +63 more
core   +3 more sources

C. elegans survival assays to discern global and transcription-coupled nucleotide excision repair

STAR Protocols, 2021
Summary: Global genome nucleotide excision repair (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) protect cells against a variety of helix-distorting DNA lesions. In C. elegans, GG-NER primarily acts in proliferative germ cells and
Melanie van der Woude, Hannes Lans
doaj  

Molecular Mechanism of Global Genome Nucleotide Excision Repair

Acta Naturae, 2014
Nucleotide excision repair (NER) is a multistep process that recognizes and eliminates a wide spectrum of damage causing significant distortions in the DNA structure, such as UV-induced damage and bulky chemical adducts. The consequences of defective NER
I. Petruseva, A. Evdokimov, O. Lavrik
semanticscholar   +1 more source

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition [PDF]

, 2012
The structure-specific endonuclease activity of the human XPF–ERCC1 complex is essential for a number of DNA processing mechanisms that help to maintain genomic integrity.
Bowles, M., Fadden, A.J., Hammonds, T., Lally, J., McDonald, Neil Q., Mouilleron, S.   +5 more
core   +1 more source

Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast

Nucleus
Replication timing during S-phase impacts mutation rates in yeast and human cancers; however, the exact mechanism involved remains unclear. Here, we analyze the impact of replication timing on UV mutagenesis in Saccharomyces cerevisiae.
Allysa Sewell, John J. Wyrick
doaj   +1 more source

DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2008
Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity
Miwa Sasaki, Shigeru Sakano, Naoko Okayama, Jumpei Akao, Tomohiko Hara, Yoshihisa Kawai, Chietaka Ohmi, Yuji Hinoda, Katsusuke Naito   +8 more
doaj   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Interpreting the dependence of mutation rates on age and time [PDF]

arXiv, 2015
Mutations can arise from the chance misincorporation of nucleotides during DNA replication or from DNA lesions that are not repaired correctly. We introduce a model that relates the source of mutations to their accumulation with cell divisions, providing a framework for understanding how mutation rates depend on sex, age and absolute time. We show that
arxiv  

Consolidate Overview of Ribonucleic Acid Molecular Dynamics: From Molecular Movements to Material Innovations

Advanced Engineering Materials, EarlyView.
Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley   +1 more source