Results 221 to 230 of about 53,532 (260)

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes. [PDF]

Nat Commun
Son K, Takhaveev V, Mor V, Yu H, Dillier E, Zilio N, Püllen NJL, Ivanov D, Ulrich HD, Sturla SJ, Schärer OD.   +10 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair. [PDF]

Methods
Kuppa S, Corless E, Caldwell CC, Spies M, Antony E.   +4 more
europepmc   +1 more source

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

Global repair is the primary nucleotide excision repair subpathway for the removal of pyrimidine-pyrimidone (6-4) damage from the Arabidopsis genome. [PDF]

Sci Rep
Kaya S, Erdogan DE, Sancar A, Adebali O, Oztas O.   +4 more
europepmc   +1 more source

Regulation of XPG-DNA damage binding dynamics by pre- and post-incision nucleotide excision repair factors and EXO1

Muniesa-Vargas A, Ribeiro-Silva C, Geverts B, Davó-Martínez C, van de Grint J, Ganpat M, Thijssen KL, Pothof J, Houtsmuller AB, Theil AF, Vermeulen W, Lans H.   +11 more
europepmc   +1 more source

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Nucleotide excision repair in yeast

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2000
In nucleotide excision repair (NER) in eukaryotes, DNA is incised on both sides of the lesion, resulting in the removal of a fragment approximately 25-30 nucleotides long. This is followed by repair synthesis and ligation. The proteins encoded by the various yeast NER genes have been purified, and the incision reaction reconstituted in vitro.
Satya Prakash, Louise Prakash
exaly   +3 more sources

At the core of nucleotide excision repair

Current Opinion in Structural Biology, 2023
Nucleotide excision repair (NER) is unique in its ability to identify and remove vastly different lesions from DNA. Recent advances in the structural characterization of complexes involved in detection, verification, and excision of damaged DNA have reshaped our understanding of the molecular architecture of this efficient and accurate machinery ...
Jochen, Kuper, Caroline, Kisker
openaire   +2 more sources

Nucleotide Excision Repair

2005
Publisher Summary DNA damage is a common occurrence that compromises the functional integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with DNA damage, including those introduced by sunlight and other environmental agents.
Joyce T, Reardon, Aziz, Sancar
openaire   +3 more sources

NUCLEOTIDE EXCISION REPAIR

Photochemistry and Photobiology, 1993
Abstract— Nucleotide excision repair is the major DNA repair mechanism in all species tested. This repair system is the sole mechanism for removing bulky adducts from DNA, but it repairs essentially all DNA lesions, and thus, in addition to its main function, it plays a back‐up role for other repair systems.
A, Sancar, M S, Tang
openaire   +2 more sources