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Phosphatemia is an Independent Prognostic Factor in Amyotrophic Lateral Sclerosis
Annals of Neurology, EarlyView.Objective The objective of this study was to evaluate the prognostic value of several muscle damage biomarkers. Methods Data from Piemonte and Valle d'Aosta Amyotrophic Lateral Sclerosis (PARALS) were considered for this study. Survival was defined as the time from diagnosis to death, tracheostomy, or the censoring date.
Rosario Vasta +18 more
wiley +1 more source
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At the core of nucleotide excision repair
Current Opinion in Structural Biology, 2023Nucleotide excision repair (NER) is unique in its ability to identify and remove vastly different lesions from DNA. Recent advances in the structural characterization of complexes involved in detection, verification, and excision of damaged DNA have reshaped our understanding of the molecular architecture of this efficient and accurate machinery ...
Jochen, Kuper, Caroline, Kisker
openaire +2 more sources
Heterogeneity and overlaps in nucleotide excision repair disorders
Clinical Genetics, 2020Nucleotide excision repair (NER) is an essential DNA repair pathway devoted to the removal of bulky lesions such as photoproducts induced by the ultraviolet (UV) component of solar radiation.
D. Ferri, D. Orioli, E. Botta
semanticscholar +1 more source
Photochemistry and Photobiology, 1993
Abstract— Nucleotide excision repair is the major DNA repair mechanism in all species tested. This repair system is the sole mechanism for removing bulky adducts from DNA, but it repairs essentially all DNA lesions, and thus, in addition to its main function, it plays a back‐up role for other repair systems.
Aziz Sancar, Moon-shong Tang
openaire +3 more sources
Abstract— Nucleotide excision repair is the major DNA repair mechanism in all species tested. This repair system is the sole mechanism for removing bulky adducts from DNA, but it repairs essentially all DNA lesions, and thus, in addition to its main function, it plays a back‐up role for other repair systems.
Aziz Sancar, Moon-shong Tang
openaire +3 more sources
Nucleotide excision repair in yeast
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2000In nucleotide excision repair (NER) in eukaryotes, DNA is incised on both sides of the lesion, resulting in the removal of a fragment approximately 25-30 nucleotides long. This is followed by repair synthesis and ligation. The proteins encoded by the various yeast NER genes have been purified, and the incision reaction reconstituted in vitro.
Satya Prakash, Louise Prakash
openaire +3 more sources
2005
Publisher Summary DNA damage is a common occurrence that compromises the functional integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with DNA damage, including those introduced by sunlight and other environmental agents.
Aziz Sancar, Joyce T. Reardon
openaire +2 more sources
Publisher Summary DNA damage is a common occurrence that compromises the functional integrity of DNA. It is not surprising then that cells have multiple mechanisms for coping with DNA damage, including those introduced by sunlight and other environmental agents.
Aziz Sancar, Joyce T. Reardon
openaire +2 more sources
Nucleotide excision repair and cancer
Journal of Molecular Histology, 2006Nucleotide excision repair (NER) is the most versatile and best studied DNA repair system in humans. NER can repair a variety of bulky DNA damages including UV-light induced DNA photoproducts. NER consists of a multistep process in which the DNA lesion is recognized and demarcated by DNA unwinding.
Petra Laspe +2 more
openaire +2 more sources
Angewandte Chemie, 2016
DNA damage response plays a key role not only in maintaining genome integrity but also in mediating the antitumor efficacy of DNA-damaging antineoplastic drugs.
Zhigang Wang, Zoufeng Xu, G. Zhu
semanticscholar +1 more source
DNA damage response plays a key role not only in maintaining genome integrity but also in mediating the antitumor efficacy of DNA-damaging antineoplastic drugs.
Zhigang Wang, Zoufeng Xu, G. Zhu
semanticscholar +1 more source
Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond.
Annual Review of Biochemistry, 2016Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these two processes. Some of its subunits also belong to complexes involved in other cellular processes,
E. Compe, J. Egly
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