Results 371 to 380 of about 127,063 (412)
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Genomic heterogeneity of nucleotide excision repair
Gene, 2000Nucleotide excision repair (NER) is one of the major cellular pathways that removes bulky DNA adducts and helix-distorting lesions. The biological consequences of defective NER in humans include UV-light-induced skin carcinogenesis and extensive neurodegeneration.
Vilhelm A. Bohr, Adayabalam S. Balajee
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Nucleotide excision repair and chromatin remodeling
European Journal of Biochemistry, 2002The organization of DNA within eukaryotic cell nuclei poses special problems and opportunities for the cell. For example, assembly of DNA into chromatin is thought to be a principle mechanism by which adventitious general transcription is repressed. However, access to genomic DNA for events such as DNA repair must be facilitated by energy‐intensive ...
Kiyoe Ura, Jeffrey J. Hayes
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Protein complexes in nucleotide excision repair
Mutation Research/DNA Repair, 1999The main pathway by which mammalian cells remove DNA damage caused by UV light and some other mutagens is nucleotide excision repair (NER). The best characterised components of the human NER process are those proteins defective in the inherited disorder xeroderma pigmentosum (XP). The proteins known to be involved in the first steps of the NER reaction
Richard D. Wood, Sofia J. Araújo
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Disorders of nucleotide excision repair
2013Deficient repair of ubiquitous errors in the genome risks faulty transcription or replication. Its direct and indirect phenotypic consequences are rare, complex, dementing, lethal disorders of children with inadequately understood overlapping genotypes and variable severity.
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Nucleotide excision repair in differentiated cells
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2007Nucleotide excision repair (NER) is the principal pathway for the removal of a wide range of DNA helix-distorting lesions and operates via two NER subpathways, i.e. global genome repair (GGR) and transcription-coupled repair (TCR). Although detailed information is available on expression and efficiency of NER in established mammalian cell lines, little
Arnoud van der Laarse +5 more
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Nucleotide Excision Repair in Man
1998Nucleotide excision repair (excision repair) is a general repair system for damaged (modified) bases. It is considered the repair system for bulky adducts, but it is also capable of eliminating all base lesions, big or small, from DNA. Damage removal is accomplished by dual incisions bracketing the lesion by a multisubunit enzyme system referred to as ...
Tadayoshi Bessho, Aziz Sancar
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The eukaryotic nucleotide excision repair pathway
Biochimie, 2003Nucleotide excision repair (NER) is the most versatile mechanism of DNA repair, recognizing and dealing with a variety of helix-distorting lesions, such as the UV-induced photoproducts cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4 PPs).
Carlos Frederico Martins Menck +4 more
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Nucleotide excision repair and the link with transcription
Trends in Biochemical Sciences, 1995Nucleotide excision repair (NER) uses the products of about 30 genes to remove a damage-containing oligonucleotide from cellular DNA. The transcription factor TFIIH is an essential component of NER. In man, defects in NER can result in three distinct genetic disorders, whose features can be ascribed to abnormalities in DNA repair or transcription.
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Nucleotide excision repair and neurological diseases
DNA Repair, 2008This review will examine the known and postulated relationships between nucleotide excision repair (NER) and neurological diseases. We will begin with a description of NER and its subpathways: global genomic repair (GGR), transcription-coupled repair (TCR) and transcription domain-associated repair (DAR).
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Understanding nucleotide excision repair and its roles in cancer and ageing
Nature reviews. Molecular cell biology, 2014J. Marteijn +3 more
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