Results 151 to 160 of about 749,080 (252)
Advanced Science, EarlyView.Based on a well‐established in vitro directed differentiation model and an integrated analysis of high‐density cell lineage trees (CLTs) and single‐cell transcriptomes, it is demonstrated that many subclones are formed by sub‐CLTs resembling each other in terms of both cell type compositions and topological structures.
Xiaoyu Zhang +14 more
wiley +1 more source
Editorial: Adenine nucleotides in immunity and inflammation. [PDF]
Front ImmunolMüller CE, Bruzzone S, Guse AH.
europepmc +1 more source
Self‐Adjusting Engineered Probiotic for Targeted Tumor Colonization and Local Therapeutics Delivery
Advanced Science, EarlyView.Zou et al. developed an engineered strain of Escherichia coli Nissle 1917 with precise targeting abilities for colonization and on‐demand payload release. The engineered probiotic survives and embolizes tumors only in the presence of more than 5 mM L‐lactate. Furthermore, the introduction of an α‐hemolysin circuit enhances its anti‐tumor effect.
Zhen‐Ping Zou +8 more
wiley +1 more source
Quantitative Super‐Resolution Imaging of Molecular Tension
Advanced Science, EarlyView.Quantitative tension PAINT (qtPAINT) is a new method to quantify molecular tension at super‐resolution by exploiting force‐dependent DNA oligonucleotide dissociation kinetics. Combining hairpin tension probes and molecular‐beacon imagers, qtPAINT achieves 9–30 pN continuous force quantification range with 30–120 nm spatial and minute‐scale temporal ...
Seong Ho Kim +4 more
wiley +1 more source
Development of CD73 Inhibitors in Tumor Immunotherapy and Opportunities in Imaging and Combination Therapy. [PDF]
J Med ChemBi C, Patel JS, Liang SH.
europepmc +1 more source
Advanced Science, EarlyView.Overview of the Genetic Deafness Commons (GDC), integrating data from the Chinese Deafness Genetics Consortium (CDGC) and 51 public databases. The GDC provides tools for variant search, functional predictions, and gene‐disease visualization, offering insights into 201 hearing loss genes and facilitating novel gene discovery and clinical applications ...
Hui Cheng +11 more
wiley +1 more source
Integrated widely targeted metabolomics and flavoromics reveal processing-driven dynamic changes in functional metabolites of <i>Eucommia ulmoides</i> leaf tea. [PDF]
Food Chem XLin Y +5 more
europepmc +1 more source
Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
Elucidating the solution structure of the monomolecular <i>BCL2</i> RNA G-quadruplex: a new robust NMR assignment approach. [PDF]
Chem SciWang Z +5 more
europepmc +1 more source