Results 241 to 250 of about 588,819 (292)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Integrated NMR and MD structure and dynamics of the stem-loop-II motif (s2m) from the Omicron variant of SARS-CoV-2. [PDF]

RNA
Matzel T, Makowski JA, Kensinger AH, Oxenfarth A, Martin MW, Evanseck JD, Schwalbe H.   +6 more
europepmc   +1 more source

Single Nucleotide Polymorphism (SNP) และ DNA Polymorphisms

, 2003
Songyot Anuchapreeda
openalex   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Synonymous and non-synonymous variants at splice junctions can disrupt splicing and are frequently linked to disease associated loss of function genes. [PDF]

BMC Genomics
Srinivasan S, Subramanian S, Zhou H, Hoppmann A, Metzger P, Boerries M, Ramamoorthy S.   +6 more
europepmc   +1 more source

Synthesis of siRNAs containing carbocyclic nucleotides and the role of cyclopentane conformation in RNAi activity. [PDF]

RSC Chem Biol
Kundu J, Datta D, Akabane-Nakata M, Mandal S, Krampert M, Egli M, Manoharan M.   +6 more
europepmc   +1 more source

A circovirus-like genomic sequence with unique architecture and phylogenetic relatedness to human-linked viral lineages. [PDF]

Front Cell Infect Microbiol
Dai L, Mao L, Shi W, Ndjekadom A, Wang X, Liu Y, Yang S, Ji L, Wang J, Ma J, Zhang W, Shen Q.   +11 more
europepmc   +1 more source

NEWLY IDENTIFIED NUCLEOTIDE SUBSTITUTIONS IN BOVINE LEUKEMIA VIRUS ISOLATES FROM THE REPUBLIC OF BASHKORTOSTAN

Maxim V. Petropavlovskiy, И. М. Донник, Natalia A. Bezborodova, Valeriya A. Makutina, Albina G. Isaeva, A. Lysov, Alisa S. Romanova   +6 more
openalex   +2 more sources

Mycophenolate mofetil reduces the branching of microglial processes. [PDF]

Mol Brain
Teruya RI, Ueda K, Taketomi T, Yamamoto T, Yamashita N, Konno H, Tsuruta F.   +6 more
europepmc   +1 more source