Results 271 to 280 of about 890,466 (364)
THE STEREOSPECIFICITY OF ENZYMATIC HYDROGEN TRANSFER FROM DIPHOSPHOPYRIDINE NUCLEOTIDE
Haim Levy, Birgit Vennesland
openalex +1 more source
Editorial: Nucleosides, nucleotides and nucleic acids: chemistry and biology
Leandro Soter de Mariz e Miranda+6 more
doaj +1 more source
UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation
This article studies the role of UFMylation in NLRP3 inflammasome activation. It reveals that UFMylation, mediated by the E3 Ufm1‐ligase 1 (Ufl1), maintains NLRP3 stability by preventing its ubiquitination and subsequent autophagic degradation.
Jiongjie Jing+14 more
wiley +1 more source
Shrimp Virus Regulates ROS Dynamics via the Nrf2 Pathway to Facilitate Viral Replication
Viruses manipulate host ROS as a strategy to achieve successful infection. WSSV exploits Nrf2 pathway to maintain ROS homeostasis and establishes a positive feedback loop to facilitate WSSV replication. Wsv220 competitively binds to Keap1 to activate Nrf2. Nrf2 up‐regulates LvG6PDH to produce more NADPH and GSH to eliminate excessive ROS.
Honghui He+6 more
wiley +1 more source
A GRP78 nanobody‐directed immunotoxin suppresses cancer progression and metastasis by enhancing antitumor immunity via STING pathway activation, offering a pan‐cancer‐targeted approach and immunotherapy combination strategy. Abstract The lack of targetable antigens poses a significant challenge in developing effective cancer‐targeted therapies.
Huifang Wang+16 more
wiley +1 more source
A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer
The hierarchical organization of the eukaryotic genome is vital for nuclear function, and disruptions from genetic mutations can alter this 3D architecture. Cataloging thousands of interchromosomal translocations, structural variants, and single nucleotide polymorphisms, their impact on 3D genome organization is revealed. The scoring algorithm, 3DFunc,
Li Tang+6 more
wiley +1 more source