Results 1 to 10 of about 5,731 (204)

Identification and characterization of a novel aminoglycoside O-nucleotidyltransferase ANT(6)-If from Paenibacillus thiaminolyticus PATH554 [PDF]

Frontiers in Microbiology, 2023
BackgroundPaenibacillus thiaminolyticus, a species of genus Paenibacillus of the family Paenibacillaceae, exists widely in environments and habitats in various plants and worms, and occasionally causes human infections.
Junwan Lu, Junwan Lu, Yuning Sha, Mengdi Gao, Weina Shi, Xi Lin, Kewei Li, Qiyu Bao, Qiyu Bao, Chunlin Feng, Chunlin Feng   +10 more
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Two complementing in vivo selection systems based on CCA-trimming exonucleases as a tool to monitor, select and evaluate enzymatic features of tRNA nucleotidyltransferases [PDF]

RNA Biology
tRNA nucleotidyltransferase represents a ubiquitous and essential activity that adds the indispensable CCA triplet to the 3’-end of tRNAs. To fulfill this function, the enzyme contains a set of highly conserved motifs whose coordinated interplay is ...
Karolin Wellner, Josefine Gnauck, Dorian Bernier, Stephan H. Bernhart, Heike Betat, Mario Mörl   +5 more
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Identification of a novel aminoglycoside nucleotidyltransferase ANT(3″)-Ic from Citrobacter telavivum S24 [PDF]

BMC Microbiology
Understanding the antibiotic resistance profile of the emerging pathogen Citrobacter telavivum S24 is important for clinical care, surveillance, and research. C. telavivum S24, a strain that exhibits resistance to both streptomycin and spectinomycin, was
Junwan Lu, Mei Zhu, Jingzeng Ye, Leyao Xu, Chunhan Song, Kewei Li, Qiyu Bao, Xi Lin   +7 more
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Nucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth [PDF]

Nature Communications
Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in humans.
Xibing Xu, Roland Barriot, Bertille Voisin, Tom J. Arrowsmith, Ben Usher, Claude Gutierrez, Xue Han, Carine Pagès, Peter Redder, Tim R. Blower, Olivier Neyrolles, Pierre Genevaux   +11 more
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Identification of a novel aminoglycoside nucleotidyltransferase gene in Morganella morganii from farm sewage [PDF]

BMC Microbiology
Background Aminoglycosides are important broad-spectrum antimicrobial agents. When combined with β-lactam drugs, these agents can be used to treat severe infections such as those causing sepsis. Identifying additional resistance mechanisms will guarantee
Junwan Lu, Jing Wang, Mengdi Gao, Kexin Zhou, Jialei Liang, Chunhan Song, Xuying He, Chaoqun Liu, Huiyue Feng, Wei Pan, Qiyu Bao, Chunxia Yan, Dawei Huang   +12 more
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Identification and characterization of a novel chromosome-encoded aminoglycoside O-nucleotidyltransferase gene, ant(9)-Id, in Providencia sp. TYF-12 isolated from the marine fish intestine [PDF]

Frontiers in Microbiology
BackgroundThe mechanisms underlying the resistance of the genus Providencia to aminoglycosides are complex, which poses a challenge for the efficient treatment of infectious diseases caused by these pathogens.
Yan Yu, Runzhi Zhang, Wei Pan, Xinyi Sheng, Susu Chen, Junjun Wang, Junwan Lu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Yunliang Hu, Pengfei Jiang, Dawei Huang   +12 more
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Noncanonical Poly(A) Polymerase TENT4 Drives Expression of Subgenomic Hepatitis A Virus RNAs in Infected Cells [PDF]

Viruses
Both hepatitis B virus (HBV), an hepadnavirus with a DNA genome, and hepatitis A virus (HAV), a picornavirus, require the TRAMP-like host ZCCHC14-TENT4 complex for efficient replication.
You Li, Ankit Gupta, Brian N. Papas, David Aponte-Diaz, Jayden M. Harris, Ichiro Misumi, Jason K. Whitmire, Craig E. Cameron, Marcos Morgan, Stanley M. Lemon   +9 more
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Structural insight into the distinct regulatory mechanism of the HEPN–MNT toxin-antitoxin system in Legionella pneumophila [PDF]

Nature Communications
HEPN–MNT, a type VII TA module, comprises the HEPN toxin and the MNT antitoxin, which acts as a nucleotidyltransferase that transfers the NMP moiety to the corresponding HEPN toxin, thereby interfering with its toxicity.
Chenglong Jin, Cha-Hee Jeon, Heung Wan Kim, Jin Mo Kang, Yuri Choi, Sung-Min Kang, Hyung Ho Lee, Do-Hee Kim, Byung Woo Han, Bong-Jin Lee   +9 more
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Identification of residues involved in nucleotidyltransferase activity of JHP933 from helicobacter pyloriby site-directed mutagenesis [PDF]

Archives of Biological Sciences, 2016
Helicobacter pylori is a well-known bacterial pathogen involved in the development of peptic ulcer, gastric adenocarcinoma and other forms of gastric cancer.
Ye Xianren, Zhao Yanhe, Wu Xiuling, Su Yintao, Wu Yunkun, She Feifei   +5 more
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Identification of a novel aminoglycoside O-nucleotidyltransferase AadA33 in Providencia vermicola

Frontiers in Microbiology, 2022
A novel chromosome-encoded aminoglycoside O-nucleotidyltransferase AadA33 was identified in Providencia vermicola strain P13. The AadA33 shares the highest amino acid identity of 51.28% with the function characterized AadA31.
Chunlin Feng, Chunlin Feng, Mengdi Gao, Weiyan Jiang, Weina Shi, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Junwan Lu, Junwan Lu, Kewei Li, Hailin Zhang, Yunliang Hu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Xi Lin, Xi Lin   +20 more
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