Results 1 to 10 of about 10,746 (269)

Identification and characterization of a novel aminoglycoside O-nucleotidyltransferase ANT(6)-If from Paenibacillus thiaminolyticus PATH554 [PDF]

Frontiers in Microbiology, 2023
BackgroundPaenibacillus thiaminolyticus, a species of genus Paenibacillus of the family Paenibacillaceae, exists widely in environments and habitats in various plants and worms, and occasionally causes human infections.
Junwan Lu, Junwan Lu, Yuning Sha, Mengdi Gao, Weina Shi, Xi Lin, Kewei Li, Qiyu Bao, Qiyu Bao, Chunlin Feng, Chunlin Feng   +10 more
doaj   +3 more sources

Nucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth [PDF]

Nature Communications
Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in humans.
Xibing Xu, Roland Barriot, Bertille Voisin, Tom J. Arrowsmith, Ben Usher, Claude Gutierrez, Xue Han, Carine Pagès, Peter Redder, Tim R. Blower, Olivier Neyrolles, Pierre Genevaux   +11 more
doaj   +3 more sources

Expanding the Substrate Scope of a Bacterial Nucleotidyltransferase via Allosteric Mutations [PDF]

ACS Infectious Diseases, 2022
Bacterial glycoconjugates, such as cell surface polysaccharides and glycoproteins, play important roles in cellular interactions and survival. Enzymes called nucleotidyltransferases use sugar-1-phosphates and nucleoside triphosphates (NTPs) to produce ...
Maggie Zheng, Meng Zheng, Tania J. Lupoli   +2 more
openalex   +2 more sources

Identification of a novel aminoglycoside O-nucleotidyltransferase AadA33 in Providencia vermicola

Frontiers in Microbiology, 2022
A novel chromosome-encoded aminoglycoside O-nucleotidyltransferase AadA33 was identified in Providencia vermicola strain P13. The AadA33 shares the highest amino acid identity of 51.28% with the function characterized AadA31.
Chunlin Feng, Chunlin Feng, Mengdi Gao, Weiyan Jiang, Weina Shi, Anqi Li, Shuang Liu, Lei Zhang, Xueya Zhang, Qiaoling Li, Hailong Lin, Junwan Lu, Junwan Lu, Kewei Li, Hailin Zhang, Yunliang Hu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Xi Lin, Xi Lin   +20 more
doaj   +2 more sources

ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia

Microbiology Spectrum, 2023
Aminoglycoside-modifying enzymes are among the most important mechanisms of resistance to aminoglycoside antibiotics, typically conferring high-level resistance by enzymatic drug inactivation.
Xiusheng Sheng, Wei Lu, Aifang Li, Junwan Lu, Chunhan Song, Jiefeng Xu, Youming Dong, Chunqing Fu, Xi Lin, Mei Zhu, Qiyu Bao, Kewei Li   +11 more
doaj   +2 more sources

A nucleotidyltransferase toxin inhibits growth of Mycobacterium tuberculosis through inactivation of tRNA acceptor stems [PDF]

Science Advances, 2020
The human pathogen Mycobacterium tuberculosis produces a toxin that can stall bacterial growth by blocking the activity of tRNAs. Toxin-antitoxin systems are widespread stress-responsive elements, many of whose functions remain largely unknown.
Yiming Cai, B. F. Usher, Claude Gutierrez, Anastasia Tolcan, Moïse Mansour, Peter C. Fineran, Ciarán Condon, Olivier Neyrolles, Pierre Genevaux, Tim R. Blower   +9 more
semanticscholar   +3 more sources

MenT nucleotidyltransferase toxins extend tRNA acceptor stems and can be inhibited by asymmetrical antitoxin binding

Nature Communications, 2023
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu, Ben Usher, Claude Gutierrez, Roland Barriot, Tom J. Arrowsmith, Xue Han, Peter Redder, Olivier Neyrolles, Tim R. Blower, Pierre Genevaux   +9 more
doaj   +2 more sources

Identification and Characterization of a Novel Aminoglycoside 3''-Nucleotidyltransferase, ANT(3'')-IId, From Acinetobacter lwoffii

Frontiers in Microbiology, 2021
A novel plasmid-encoded aminoglycoside 3''-nucleotidyltransferase ANT(3")-IId, was discovered in Acinetobacter lwoffi strain H7 isolated from a chick on an animal farm in Wenzhou, China. The whole-genome of A.
Jialei Liang, Jialei Liang, Kexin Zhou, Kexin Zhou, Qiaoling Li, Qiaoling Li, Xu Dong, Xu Dong, Peiyao Zhang, Peiyao Zhang, Hongmao Liu, Hongmao Liu, Hailong Lin, Hailong Lin, Xueya Zhang, Xueya Zhang, Junwan Lu, Junwan Lu, Xi Lin, Xi Lin, Kewei Li, Kewei Li, Teng Xu, Hailin Zhang, Hailin Zhang, Qiyu Bao, Qiyu Bao, Mei Zhu, Yunliang Hu, Yunliang Hu, Ping Ren, Ping Ren   +31 more
doaj   +2 more sources

AadA36, a novel chromosomal aminoglycoside nucleotidyltransferase from a clinical isolate of Providencia stuartii

Frontiers in Microbiology, 2022
In this study, we characterized a novel chromosome-encoded aminoglycoside nucleotidyltransferase (ANT), AadA36, from the Providencia stuartii strain P14 isolated from the sputum specimen of a burn patient at a hospital in Wenzhou, China.
Mengdi Gao, Mengdi Gao, Chunlin Feng, Yongan Ji, Yaokai Shi, Weina Shi, Lei Zhang, Shuang Liu, Anqi Li, Xueya Zhang, Xueya Zhang, Qiaoling Li, Qiaoling Li, Junwan Lu, Qiyu Bao, Qiyu Bao, Qiyu Bao, Hailin Zhang   +17 more
doaj   +2 more sources

Nucleotide specificity of the human terminal nucleotidyltransferase Gld2 (TUT2) [PDF]

RNA: A publication of the RNA Society, 2016
The nontemplated addition of single or multiple nucleotides to RNA transcripts is an efficient means to control RNA stability and processing. Cytoplasmic RNA adenylation and the less well-known uridylation are post-transcriptional mechanisms regulating ...
Christina Z. Chung, David Hyung Suk Jo, Ilka U. Heinemann   +2 more
openalex   +2 more sources