Results 21 to 30 of about 5,731 (204)
Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity. [PDF]
PLoS ONE, 2012 Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome.
So Maezawa +12 more
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Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress. [PDF]
PLoS Genetics, 2013 Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels.
Andreas Czech +4 more
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On the ancestral UDP-glucose pyrophosphorylase activity of GalF from Escherichia coli
Frontiers in Microbiology, 2015 In bacteria, UDP-glucose is a central intermediate in carbohydrate metabolism. The enzyme responsible for its synthesis is encoded by the galU gene and its deletion generates cells unable to ferment galactose.
Ana C Ebrecht +6 more
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Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
Frontiers in Genetics, 2014 The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Kozo eTomita, Seisueke eYamashita
doaj +1 more source
Nature Communications, 2023 Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M.
Xibing Xu +9 more
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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
Cell Reports, 2013 Innate immune recognition of foreign nucleic acids induces protective interferon responses. Detection of cytosolic DNA triggers downstream immune signaling through activation of cyclic GMP-AMP synthase (cGAS).
Philip J. Kranzusch +3 more
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PLoS Genetics, 2017 The emergence and spread of antibiotic resistance among Acinetobacter spp. have been investigated extensively. Most studies focused on the multiple antibiotic resistance genes located on plasmids or genomic resistance islands.
Gang Zhang +7 more
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Critical Minireview: The Fate of tRNACys during Oxidative Stress in Bacillus subtilis
Biomolecules, 2017 Oxidative stress occurs when cells are exposed to elevated levels of reactive oxygen species that can damage biological molecules. One bacterial response to oxidative stress involves disulfide bond formation either between protein thiols or between ...
Juan Campos Guillen +8 more
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The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis
Nature Communications, 2019 Phosphonate modifications can be present on microbial cell surfaces. Here the authors perform bioinformatics analyses and observe a widespread occurrence of nucleotidyltransferase-encoding genes in bacterial phosphonate biosynthesis and functionally ...
Kyle Rice +14 more
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A Novel Pathway of Functional microRNA Uptake and Mitochondria Delivery
Advanced Science, 2023 Extracellular microRNAs (miRNAs) play a critical role in horizontal gene regulation. Uptake of extracellular miRNAs by recipient cells and their intracellular transport, however, remains elusive.
Jiachen Liu +13 more
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