Results 31 to 40 of about 5,408 (205)
Frontiers in Microbiology, 2022 In this study, we characterized a novel chromosome-encoded aminoglycoside nucleotidyltransferase (ANT), AadA36, from the Providencia stuartii strain P14 isolated from the sputum specimen of a burn patient at a hospital in Wenzhou, China.
Mengdi Gao +17 more
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Ubiquitylation of terminal deoxynucleotidyltransferase inhibits its activity. [PDF]
PLoS ONE, 2012 Terminal deoxynucleotidyltransferase (TdT), which template-independently synthesizes DNA during V(D)J recombination in lymphoid cells, is ubiquitylated by a BPOZ-2/Cul3 complex, as the ubiquitin ligase, and then degraded by the 26 S proteasome.
So Maezawa +12 more
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Reversible and rapid transfer-RNA deactivation as a mechanism of translational repression in stress. [PDF]
PLoS Genetics, 2013 Stress-induced changes of gene expression are crucial for survival of eukaryotic cells. Regulation at the level of translation provides the necessary plasticity for immediate changes of cellular activities and protein levels.
Andreas Czech +4 more
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On the ancestral UDP-glucose pyrophosphorylase activity of GalF from Escherichia coli
Frontiers in Microbiology, 2015 In bacteria, UDP-glucose is a central intermediate in carbohydrate metabolism. The enzyme responsible for its synthesis is encoded by the galU gene and its deletion generates cells unable to ferment galactose.
Ana C Ebrecht +6 more
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The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives [PDF]
Biochemical Journal, 1968 The inhibition by diethylstilboestrol of DNA nucleotidyltransferase isolated from calf thymus was studied. The inhibition exercised by diethylstilboestrol appears to obey competitive kinetics with respect to DNA primer. The activities of both replicative and terminal enzymes were affected to the same extent. There was no evidence of binding between DNA
K Griffiths, A R Fahmy
openaire +3 more sources
Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases
Frontiers in Genetics, 2014 The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Kozo eTomita, Seisueke eYamashita
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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
Cell Reports, 2013 Innate immune recognition of foreign nucleic acids induces protective interferon responses. Detection of cytosolic DNA triggers downstream immune signaling through activation of cyclic GMP-AMP synthase (cGAS).
Philip J. Kranzusch +3 more
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The Synthesis and Properties of the Sepharose‐Bound tRNA Nucleotidyltransferase [PDF]
European Journal of Biochemistry, 1971 The synthesis of an insoluble tRNA nucleotidyltransferase by covalent coupling of the enzyme to cyanogen bromide‐activated sepharose is described. The sepharose‐bound enzyme is active in the repair of the pCpCpA sequence of tRNA. Most of its properties are identical to the soluble enzyme although its stability, regarding thermal inactivation and ...
Simon Litvak +3 more
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Functions and mechanisms of
WIREs RNA, 2020 AbstractTermini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all classes of RNA species have been shown to acquire nontemplated nucleotides that are added by terminal nucleotidyltransferases (TENTs). The best‐described role of 3′ tailing is the bulk polyadenylation of messenger RNAs in the cell nucleus that is catalyzed
Vladyslava Liudkovska +2 more
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PLoS Genetics, 2017 The emergence and spread of antibiotic resistance among Acinetobacter spp. have been investigated extensively. Most studies focused on the multiple antibiotic resistance genes located on plasmids or genomic resistance islands.
Gang Zhang +7 more
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