Results 51 to 60 of about 5,731 (204)
Expanding the Substrate Scope of a Bacterial Nucleotidyltransferase via Allosteric Mutations [PDF]
, 2022 Maggie Zheng +2 more
openalex +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.This study characterizes the genetic diversity of Pseudolactococcus laudensis and Pseudolactococcus raffinolactis regarding cell wall polysaccharides (CWPS) and exopolysaccharide (EPS) biosynthesis, uncovering novel genotypes and biosynthetic pathways.
Axel Soto‐Serrano +9 more
wiley +1 more source
The Terminal Nucleotidyltransferase of Calf Thymus Nuclei
Journal of Biological Chemistry, 1966 Abstract An enzyme from calf thymus nuclei which incorporates ribonucleotides or deoxyribonucleotides into terminal positions of deoxyribonucleic acid has been purified and its mechanism of action elucidated. Distinctions between this enzyme and replicative deoxynucleotidyltransferase (DNA polymerase), the terminal deoxynucleotidyltransferase of calf ...
M E, Gottesman, E S, Canellakis
openaire +2 more sources
MicrobiologyOpen, Volume 14, Issue 6, December 2025.Lactococcus petauri predominated in isolates from outbreaks of lactococcosis, suggesting a shift in disease aetiology. Genomic analysis revealed diverse virulence factors, prophage and resistance genes, while antimicrobial susceptibility testing showed uniform resistance to common antibiotics found in farming systems, emphasising the need for ...
Adam M. Blanchard +9 more
wiley +1 more source
The Molecular Structure and Case Fatality Rate of COVID-19
Translational Research in Urology, 2020 A new coronavirus recognized as 2019 novel coronavirus (COVID-19) is the etiological cause in charge of the 2019-2020 viral pneumonia worldwide outbreak. The molecular structure and genome of this virus are identical to SARA-CoV and for an unknown reason,
Zahra Sadat Aghamir +2 more
doaj +1 more source
MicrobiologyOpen, Volume 14, Issue 6, December 2025.The novel Paenibacillus sp. strain 210, isolated from Brazilian crude oil, its genome encoding 259 carbohydrate‐active enzymes for degrading cellulose, xylan, and pectin, positioning it as a candidate for biofuel production. The strain harbors complete pathways for B‐vitamin biosynthesis and antimicrobial biosynthetic clusters (e.g., fusaricidin and ...
João Victor dos Anjos Almeida +5 more
wiley +1 more source
Virulence, 2020 The proliferation of antibiotic resistance has its origins in horizontal gene transfer. The class 1 integrons mediate gene transfer by assimilating antibiotic-resistance genes through site-specific recombination.
Jun Zhang +8 more
doaj +1 more source
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.The context‐dependent duality of cGAS–STING signalling in urologic tumours is revealed. Targeting the STING pathway, in combination with immunotherapies and gene therapies, enhances the anti‐tumour response. Sex hormone differences in urological malignancies are correlated with the cGAS–STING pathway.
Qi Wei +4 more
wiley +1 more source
Mechanism of Mg2+-Accompanied Product Release in Sugar Nucleotidyltransferases [PDF]
Structure, 2018 The nucleotidyl transfer reaction, catalyzed by sugar nucleotidyltransferases (SNTs), is assisted by two active site Mg2+ ions. While studying this reaction using X-ray crystallography, we captured snapshots of the pyrophosphate (product) as it exits along a pocket.
Vithani, Neha +6 more
openaire +3 more sources