Results 61 to 70 of about 5,731 (204)

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Advances and Strategies in Enhancing mRNA Cancer Vaccines

Advanced Materials, Volume 37, Issue 42, October 23, 2025.
Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang, Shengqi Chen, Haijun Hu, Yenhui Ong, Qianqian Ni   +4 more
wiley   +1 more source

Antimicrobial Susceptibility Profile of Escherichia coli Isolates From Artisanal Colonial Cheese in Southern Brazil

Food Safety and Health, Volume 3, Issue 4, Page 659-667, October 2025.
This study evaluated the antimicrobial susceptibility profile of Escherichia coli isolated from artisanal colonial cheese from Brazil. Sixty percent of the isolates showed resistance to at least one antimicrobial, no ESBL was found, genes blaTEM and tetB were found simultaneously in four isolates.
Luísa Aimée Schmitt Lobe, Vanessa Cortina Zanetti, Natália Regina Coldebella Ferreira, Matheus Viapiana Frutuoso, Isadora Caroline Marian, Emanueli Marchesan Maran, Manuela Maggiora Freitas Bastos, Julia Eduarda Munaretto, Gustavo Rocha, Mateus Rocha Ribas, Victor Felipe Wolleck, Francisco Lucas Amorim Nascimento, Jussara Kasuko Palmeiro, Marília Miotto‐Lindner, Silvani Verruck   +14 more
wiley   +1 more source

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +1 more source

The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of Acinetobacter baumannii From the Indigenous Orang Asli Community in Peninsular Malaysia

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Analysis of Acinetobacter baumannii from healthy individuals in a rural Malaysian community revealed significant genetic diversity, including novel sequence types. These isolates carry resistance genes and resemble clinical strains, highlighting their potential to cause disease despite their commensal origin.
Soo‐Sum Lean, Denise E. Morris, Rebecca Anderson, Ahmed Ghazi Alattraqchi, David W. Cleary, Stuart C. Clarke, Chew Chieng Yeo   +6 more
wiley   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, Volume 599, Issue 18, Page 2674-2684, September 2025.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Comprehensive Pan‐Cancer Analysis of TRNT1 as a Potential Biomarker for Breast Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT TRNT1, an RNA nucleotide transferase, plays a critical role in cellular processes and may be involved in cancer. However, its role in cancer has not been fully explored. This study aims to explore the potential significance of TRNT1 in cancer, particularly in breast cancer (BC) progression and prognosis.
Xinwei Li, Yue Meng, Bing Gu
wiley   +1 more source

Stress alters hypothalamic gene expression in adolescent male Golden hamsters

Journal of Neuroendocrinology, Volume 37, Issue 9, September 2025.
Abstract In Golden hamsters (Mesocricetus auratus), a two‐week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long‐term increased body weight.
Kevin M. Moran, Tyler M. Milewski, James P. Curley, Yvon Delville   +3 more
wiley   +1 more source

Novel biallelic TRNT1 mutations lead to atypical SIFD and multiple immune defects

Genes and Diseases, 2020
Mutations in the gene encoding transfer RNA (tRNA) nucleotidyltransferase, CCA-adding 1 (TRNT1), an enzyme essential for the synthesis of the 3′-terminal CCA sequence in tRNA molecules, are associated with a rare syndrome of congenital sideroblastic ...
Lu Yang, Xiuhong Xue, Ting Zeng, Xuemei Chen, Qin Zhao, Xuemei Tang, Jun Yang, Yunfei An, Xiaodong Zhao   +8 more
doaj   +1 more source

Enriched Shotgun Sequencing to Assess the Effects of Interventions to Reduce Antimicrobial Use in Neonatal Dairy Calves

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT Background Neonatal diarrhea accounts for 20%–25% of morbidity among calves, and antimicrobial drugs (AMDs) are often administered for treatment. Systematic approaches that mitigate antimicrobial use (AMU) can be effective in decreasing antimicrobial resistance (AMR).
Rebecca Flancman, Enrique Doster, Diego E. Gomez, Nicole Ricker, Paul S. Morley, J. Scott Weese   +5 more
wiley   +1 more source