Results 61 to 70 of about 5,408 (205)

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, EarlyView.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

Towards the control of biofilm formation in Anabaena (Nostoc) sp. PCC7120: novel insights into the genes involved and their regulation

New Phytologist, EarlyView.
Summary Cyanobacteria are major components of biofilms in light‐exposed environments, contributing to nutrient cycling, nitrogen fixation and global biogeochemical processes. Although nitrogen‐fixing cyanobacteria have been successfully used in biofertilization, the regulatory mechanisms underlying biofilm formation remain poorly understood.
Irene Olivan‐Muro, Jorge Guío, Germán Alonso‐Tolo, Emma Sevilla, María F. Fillat   +4 more
wiley   +1 more source

Unlocking Enhanced Efficacy of Aminoglycoside Antibiotics Against Pseudomonas aeruginosa

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
This opinion article reviews the use and challenges of aminoglycosides on the Gram‐negative pathogen Pseudomonas aeruginosa and highlights recent discoveries of adjuvants and/or other compounds that potentiate the activity of these antibiotics. ABSTRACT Infectious diseases continue to be a global health burden.
Patrick Ofori Tawiah, Sadia Sultana, Jan‐Ulrik Dahl   +2 more
wiley   +1 more source

Aminoglycoside riboswitch control of the expression of integron associated aminoglycoside resistance adenyltransferases

Virulence, 2020
The proliferation of antibiotic resistance has its origins in horizontal gene transfer. The class 1 integrons mediate gene transfer by assimilating antibiotic-resistance genes through site-specific recombination.
Jun Zhang, Getong Liu, Xuhui Zhang, Yaowen Chang, Shasha Wang, Weizhi He, Wenxia Sun, Dongrong Chen, Alastair I.H. Murchie   +8 more
doaj   +1 more source

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Advanced Science, Volume 12, Issue 19, May 22, 2025.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo   +8 more
wiley   +1 more source

Multi‐Omic Analysis of Glutamate Excitotoxicity in Primary Neuronal Cultures [PDF]

J Neurochem
Our study on rat neuron cells found 250 μM glutamate to be toxic, causing neuron death. We identified genes in pathways linked to apoptosis, neuron plasticity, and cell signaling, along with proteins regulating the cell cycle and tumor proliferation.
Nguyen J, Zhang X, Eby H, Alganem K, Ryan W, lmami A, Lundh A, Madhavaram A, Bretz J, Tackie‐Yarboi E, Zajac K, Messer W, Schiefer I, McCullumsmith R.   +13 more
europepmc   +2 more sources

Transcriptome atlas of Striga germination: Implications for managing an intractable parasitic plant

PLANTS, PEOPLE, PLANET, Volume 7, Issue 2, Page 396-410, March 2025.
Witchweeds, parasitic plants of the genus Striga, are nicknamed “cereal killers” because of their devastating destruction of Africa's most staple cereals, including maize, sorghum, millets, and upland rice. The parasite relies on biomolecules emitted from the host roots to germinate and therefore initiate its infectious lifecycle.
Gilles Irafasha, Sylvia Mutinda, Fredrick Mobegi, Brett Hale, George Omwenga, Asela J. Wijeratne, Susann Wicke, Emily S. Bellis, Steven Runo   +8 more
wiley   +1 more source

Kinetic analysis of rabbit liver tRNA nucleotidyltransferase.

Journal of Biological Chemistry, 1978
The kinetic properties of rabbit liver tRNA nucleotidyltransferase were examined. Our results indicate that incorporation of AMP into tRNA-C-C at pH 9.4 proceeds by a rapid equilibrium Random Bi Bi mechanism. This conclusion was supported by bisubstrate initial velocity studies, dead end and product inhibition, and isotope exchange at equilibrium and ...
M.P. Deutscher, J.A. Evans
openaire   +3 more sources

Capsular Typing and Molecular Characterization of Streptococcus agalactiae Strains Isolated From Bovine Mastitis in Iran

Veterinary Medicine and Science, Volume 11, Issue 2, March 2025.
The following three main findings were obtained from the present study: 1‐ The most common capsular serotype identified in Streptococcus agalactiae strains isolated from bovine mastitis cases was serotype Number III. 2‐ Most of the Streptococcus agalactiae strains isolated from bovine mastitis were antibiotic resistant to antibiotics commonly used in ...
Pegah HajiAhmadi, Hassan Momtaz, Elahe Tajbakhsh   +2 more
wiley   +1 more source

Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?

The FEBS Journal, Volume 292, Issue 6, Page 1252-1264, March 2025.
Ruminococcus gnavus (R. gnavus) can degrade mucin, modify bile acids, and secrete metabolites into circulation via the portal vein to the liver for further processing and subsequent systemic circulation. R. gnavus is associated with metabolic syndrome and inflammatory bowel disease severity. It is suspected that R.
Vik Meadows, Jayson M. Antonio, Ronaldo P. Ferraris, Nan Gao   +3 more
wiley   +1 more source