Results 71 to 80 of about 5,408 (205)

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +1 more source

Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer

Helicobacter, Volume 30, Issue 2, March/April 2025.
ABSTRACT Background Helicobacter pylori (H. pylori) has been identified as a type I carcinogen and contributes to a high rate of gastric cancer (GC), especially in Eastern Asia. Extracellular vesicles (EVs) have the potential to be used to detect various cancer types and diseases. However, the protein markers in EVs for the prognosis of H.
Phawinee Subsomwong, Krisana Asano, Junko Akada, Takashi Matsumoto, Akio Nakane, Yoshio Yamaoka   +5 more
wiley   +1 more source

Circ-PNPT1 contributes to gestational diabetes mellitus (GDM) by regulating the function of trophoblast cells through miR-889-3p/PAK1 axis

Diabetology & Metabolic Syndrome, 2021
Background Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. CircRNA polyribonucleotide nucleotidyltransferase 1 (circ-PNPT1) has been found to be abnormally expressed in GDM patients.
Li Zhang, Ming Zeng, Fei Tang, Jun Chen, Dongmei Cao, Ze-nan Tang   +5 more
doaj   +1 more source

Transcription Kinetics in the Coronavirus Life Cycle

WIREs RNA, Volume 16, Issue 1, January/February 2025.
The steps involved in a Coronavirus infection are interconnected and exhibit complex kinetics, with some processes depending on each other, while others occur independently. Understanding the basic kinetics of major processes like translation, transcription, and virion assembly in the Coronavirus life cycle adds temporal resolution to the classical ...
Katarzyna Grelewska‐Nowotko, Ahmed Eisa Elhag, Tomasz Wojciech Turowski   +2 more
wiley   +1 more source

Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes

Traffic, Volume 26, Issue 1-3, January/March 2025.
TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis. ABSTRACT The serine/threonine kinase, Tank Binding Kinase 1 (TBK1), drives distinct cellular processes like innate immune signaling, selective autophagy, and mitosis. It is suggested that the translocation and
Swagatika Paul, Sahitya Ranjan Biswas, Julia P. Milner, Porter L. Tomsick, Alicia M. Pickrell   +4 more
wiley   +1 more source

Early Inoculation of Microbial Suspension in Suckling Piglets Affects the Transmission of Maternal Microbiota and the Associated Antibiotic Resistance Genes

Microorganisms, 2020
Antibiotic resistance of microbes thriving in the animal gut is a growing concern for public health as it may serve as a hidden reservoir for antibiotic resistance genes (ARGs).
Caroline S. Achard, Veronique Dupouy, Laurent Cauquil, Nathalie Arpaillange, Alain Bousquet-Melou, Nathalie Le Floc’h, Olivier Zemb   +6 more
doaj   +1 more source

Whole‐Genome Sequencing and Functional Analysis of Klebsiella Strain mr‐1S Originating From Macrobrachium rosenbergii

Aquaculture Research, Volume 2025, Issue 1, 2025.
Background:Klebsiella mr‐1S, a newly emerging pathogen that poses a substantial threat to public health by inducing severe infectious diseases, has been detected in Macrobrachium rosenbergii for the first time in our prior investigation. Given its potential for environmental adaptation and genomic evolution, this study aims to delve into these aspects ...
Yang Xu, Ying Zhao, Haihua Cheng, Fei Peng, Qiang Gao   +4 more
wiley   +1 more source

Losing the stem-loop structure from metazoan mitochondrial tRNAs and co-evolution of interacting factors

Frontiers in Genetics, 2014
Conventional tRNAs have highly conserved sequences, four-armed cloverleaf secondary structures, and L-shaped tertiary structures. However, metazoan mitochondrial tRNAs contain several exceptional structures.
Yoh-ichi eWatanabe, Takuma eSuematsu, Takashi eOhtsuki   +2 more
doaj   +1 more source

The landscape of Arabidopsis tRNA aminoacylation

The Plant Journal, Volume 120, Issue 6, Page 2784-2802, December 2024.
SUMMARY The function of transfer RNAs (tRNAs) depends on enzymes that cleave primary transcript ends, add a 3′ CCA tail, introduce post‐transcriptional base modifications, and charge (aminoacylate) mature tRNAs with the correct amino acid. Maintaining an available pool of the resulting aminoacylated tRNAs is essential for protein synthesis.
Luis F. Ceriotti, Jessica M. Warren, M. Virginia Sanchez‐Puerta, Daniel B. Sloan   +3 more
wiley   +1 more source

Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges

Marine Drugs, 2010
2′,5′-oligoadenylate synthetases (OAS) as a component of mammalian interferon-induced antiviral enzymatic system catalyze the oligomerization of cellular ATP into 2′,5′-linked oligoadenylates (2-5A).
Merike Kelve, Arno Pihlak, Indrek Tammiste, Anne Kuusksalu, Tönu Reintamm, Annika Lopp   +5 more
doaj   +1 more source