Results 71 to 80 of about 5,731 (204)

A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production

Cell Reports, 2019
Summary: A hallmark of chronic hepatitis B (CHB) virus infection is the presence of high circulating levels of non-infectious small lipid HBV surface antigen (HBsAg) vesicles.
Anastasia Hyrina, Christopher Jones, Darlene Chen, Scott Clarkson, Nadire Cochran, Paul Feucht, Gregory Hoffman, Alicia Lindeman, Carsten Russ, Frederic Sigoillot, Tiffany Tsang, Kyoko Uehara, Lili Xie, Don Ganem, Meghan Holdorf   +14 more
doaj   +1 more source

Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance

Cell Reports
Summary: Intratumoral heterogeneity plays a pivotal role in cancer evolution, providing the substrate for adaptation to selective pressures, including chemotherapy treatment.
Gatikrushna Singh, Shilpi Singh, Iteeshree Mohapatra, Stefan Kim, Mayur Sharma, Johnny Akers, Thien Nguyen, Eric Wong, Margot Martinez Moreno, Efrosini Kokkoli, Shobha Vasudevan, Sean E. Lawler, Wafik S. El-Deiry, Ziya Gokaslan, Clark C. Chen   +14 more
doaj   +1 more source

Case of Mitochondrial Encephalomyopathy secondary to COVID-19 in a Pediatric case of SIFD syndrome with a novel TRNT1 mutation

Clinical Immunology Communications
Syndrome of Congenital Sideroblastic Anemia, B-cell Immunodeficiency, Periodic Fevers, and Developmental Delay (SIFD) is caused by mutations in the tRNA nucleotidyltransferase 1 (TRNT1) gene.
Amer Khojah, Lauren Gunderman, Ameera Bukhari, Aisha Mirza, Madeline Schutt, Aisha Ahmed   +5 more
doaj   +1 more source

Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges

Marine Drugs, 2010
2′,5′-oligoadenylate synthetases (OAS) as a component of mammalian interferon-induced antiviral enzymatic system catalyze the oligomerization of cellular ATP into 2′,5′-linked oligoadenylates (2-5A).
Merike Kelve, Arno Pihlak, Indrek Tammiste, Anne Kuusksalu, Tönu Reintamm, Annika Lopp   +5 more
doaj   +1 more source

Kinetic analysis of rabbit liver tRNA nucleotidyltransferase.

Journal of Biological Chemistry, 1978
The kinetic properties of rabbit liver tRNA nucleotidyltransferase were examined. Our results indicate that incorporation of AMP into tRNA-C-C at pH 9.4 proceeds by a rapid equilibrium Random Bi Bi mechanism. This conclusion was supported by bisubstrate initial velocity studies, dead end and product inhibition, and isotope exchange at equilibrium and ...
J A, Evans, M P, Deutscher
openaire   +2 more sources

Losing the stem-loop structure from metazoan mitochondrial tRNAs and co-evolution of interacting factors

Frontiers in Genetics, 2014
Conventional tRNAs have highly conserved sequences, four-armed cloverleaf secondary structures, and L-shaped tertiary structures. However, metazoan mitochondrial tRNAs contain several exceptional structures.
Yoh-ichi eWatanabe, Takuma eSuematsu, Takashi eOhtsuki   +2 more
doaj   +1 more source

Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase

Cell Reports
Summary: The Piwi/Piwi-interacting RNA (piRNA) pathway protects genome integrity in animal germ lines. Maturation of piRNAs involves nucleolytic processing at both 5′ and 3′ ends.
Benjamin Pastore, Hannah L. Hertz, Wen Tang   +2 more
doaj   +1 more source

Agrobacterium VirD2-Binding Protein Is Involved in Tumorigenesis and Redundantly Encoded in Conjugative Transfer Gene Clusters

Molecular Plant-Microbe Interactions, 2007
Agrobacterium tumefaciens can transfer oncogenic T-DNA into plant cells; T-DNA transfer is mechanistically similar to a conjugation process. VirD2 is the pilot protein that guides the transfer, because it is covalently associated with single-stranded T ...
Minliang Guo, Qingming Hou, Choy L. Hew, Shen Q. Pan   +3 more
doaj   +1 more source

A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans

G3: Genes, Genomes, Genetics, 2019
The human pathogenic yeast Cryptococcus neoformans silences transposable elements using endo-siRNAs and an Argonaute, Ago1. Endo-siRNAs production requires the RNA-dependent RNA polymerase, Rdp1, and two partially redundant Dicer enzymes, Dcr1 and Dcr2 ...
Jordan E. Burke, Adam D. Longhurst, Prashanthi Natarajan, Beiduo Rao, John Liu, Jade Sales-Lee, Yasaman Mortensen, James J. Moresco, Jolene K. Diedrich, John R. Yates, Hiten D. Madhani   +10 more
doaj   +1 more source

Function and Regulation of Human Terminal Uridylyltransferases

Frontiers in Genetics, 2018
RNA uridylylation plays a pivotal role in the biogenesis and metabolism of functional RNAs, and regulates cellular gene expression. RNA uridylylation is catalyzed by a subset of proteins from the non-canonical terminal nucleotidyltransferase family.
Yuka Yashiro, Kozo Tomita
doaj   +1 more source