Results 41 to 50 of about 1,534,545 (314)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Endoplasmic reticulum stress-related prognosis signature characterizes the immune landscape and predicts the prognosis of colon adenocarcinoma

Frontiers in Genetics
BackgroundColon adenocarcinoma (COAD) is characterized by high mortality and poor prognosis. Endoplasmic reticulum stress-related gene (ERSG) plays an indispensable role in the progression and immunotherapy of COAD.
Lichao Cao, Lichao Cao, Lichao Cao, Lichao Cao, Haoyang Dai, Haoyang Dai, Shangqing Wei, Shangqing Wei, Ying Ba, Ying Ba, Ying Ba, Fang Chen, Fang Chen, Fang Chen, Yingying Chen, Yingying Chen, Yingying Chen, Chendi Yu, Chendi Yu, Chendi Yu, Shenrui Zhang, Shenrui Zhang, Shenrui Zhang, Erfei Chen, Erfei Chen, Erfei Chen, Hezi Zhang, Hezi Zhang, Hezi Zhang   +28 more
doaj   +1 more source

Unusual Features of Pomoviral RNA Movement

Frontiers in Microbiology, 2011
Potato mop-top pomovirus (PMTV) is one of a few viruses that can move systemically in plants in the absence of the coat protein (CP). Pomoviruses encode the triple gene block genetic module of movement proteins (TGB 1, 2 & 3) and recent research ...
Lesley eTorrance, Kathryn eWright, Francois eCrutzen, Graham eCowan, Nina eLukhovitskaya, Claude eBragard, Eugene eSavenkov   +6 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Automatic Detection Method for Cancer Cell Nucleus Image Based on Deep-Learning Analysis and Color Layer Signature Analysis Algorithm

Sensors, 2020
Exploring strategies to treat cancer has always been an aim of medical researchers. One of the available strategies is to use targeted therapy drugs to make the chromosomes in cancer cells unstable such that cell death can be induced, and the elimination
Hsing-Hao Su, Hung-Wei Pan, Chuan-Pin Lu, Jyun-Jie Chuang, Tsan Yang   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Hagfish Gland Thread Cell: A Fiber-Producing Cell Involved in Predator Defense

Cells, 2016
Fibers are ubiquitous in biology, and include tensile materials produced by specialized glands (such as silks), extracellular fibrils that reinforce exoskeletons and connective tissues (such as chitin and collagen), as well as intracellular filaments ...
Douglas S. Fudge, Sarah Schorno
doaj   +1 more source

The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus

Cells, 2021
Here, we provide evidence for the presence of Myosin phosphatase rho-interacting protein (MPRIP), an F-actin-binding protein, in the cell nucleus. The MPRIP protein binds to Phosphatidylinositol 4,5-bisphosphate (PIP2) and localizes to the nuclear ...
Can Balaban, Martin Sztacho, Michaela Blažíková, Pavel Hozák   +3 more
doaj   +1 more source

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

EMBO Journal, 2012
The lysosome plays a key role in cellular homeostasis by controlling both cellular clearance and energy production to respond to environmental cues. However, the mechanisms mediating lysosomal adaptation are largely unknown.
C. Settembre, R. Zoncu, D. Medina, Francesco Vetrini, Serkan Erdin, S. Erdin, Tuong Huynh, Mathieu Ferron, G. Karsenty, M. Vellard, V. Facchinetti, D. Sabatini, A. Ballabio   +12 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source