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The nuclei of differentiating cells exhibit several fundamental principles of self‐organization. They are composed of many dynamical units connected physically and functionally to each other—a complex network—and the different parts of the system are mutually adapted and produce a characteristic end state.
Stephen J. Tapscott+5 more
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Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function
Adhesive cues from the extracellular matrix (ECM) specify the size and shape of the nucleus via mechanical forces transmitted through the cytoskeleton.
Oscar J. Pundel+2 more
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Chromatin and Nuclear Dynamics in the Maintenance of Replication Fork Integrity
Replication of the eukaryotic genome is a highly regulated process and stringent control is required to maintain genome integrity. In this review, we will discuss the many aspects of the chromatin and nuclear environment that play key roles in the ...
Jack Wootton, Evi Soutoglou
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Global Properties of Nucleus–Nucleus Collisions [PDF]
In this lecture note, we discuss the global properties of nucleus-nucleus collisions. After a brief introduction to heavy-ion collisions, we introduce useful kinematics and then discuss the bulk hadron production in A+A collisions. At the end we discuss the hadronization and hadronic freeze-out in A+A collisions.
Raghunath Sahoo+3 more
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BackgroundCellular senescence (CS) is believed to be a major factor in the evolution of cancer. However, CS-related lncRNAs (CSRLs) involved in colon cancer regulation are not fully understood.
Lichao Cao+18 more
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The mitochondrial and nuclear genomes of Eukaryotes are inherited separately and consequently follow distinct evolutionary paths. Nevertheless, the encoding of many mitochondrial proteins by the nuclear genome shows the high level of integration they ...
Pierre-Henri Clergeot, Åke Olson
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The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating ...
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Dispersive contribution to the nucleus-nucleus potential [PDF]
With a simple parametrization of the empirical imaginary potential depths, the real potential induced by a dispersion relation is calculated analytically for the elastic scattering of O16 by several target nuclei. Between 25e50 % of the real potential empirical depths can be attributed to this dispersive contribution when the energy approaches the ...
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Background Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP ...
Paulo Roberto Stevanato Filho+11 more
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Dynamic Virus-Dependent Subnuclear Localization of the Capsid Protein from a Geminivirus
Viruses are intracellular parasites with a nucleic acid genome and a proteinaceous capsid. Viral capsids are formed of at least one virus-encoded capsid protein (CP), which is often multifunctional, playing additional non-structural roles during the ...
Liping Wang+9 more
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