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Networking the nucleus

open access: yesMolecular Systems Biology, 2010
The nuclei of differentiating cells exhibit several fundamental principles of self‐organization. They are composed of many dynamical units connected physically and functionally to each other—a complex network—and the different parts of the system are mutually adapted and produce a characteristic end state.
Stephen J. Tapscott   +5 more
openaire   +4 more sources

Extracellular Adhesive Cues Physically Define Nucleolar Structure and Function

open access: yesAdvanced Science, 2022
Adhesive cues from the extracellular matrix (ECM) specify the size and shape of the nucleus via mechanical forces transmitted through the cytoskeleton.
Oscar J. Pundel   +2 more
doaj   +1 more source

Chromatin and Nuclear Dynamics in the Maintenance of Replication Fork Integrity

open access: yesFrontiers in Genetics, 2021
Replication of the eukaryotic genome is a highly regulated process and stringent control is required to maintain genome integrity. In this review, we will discuss the many aspects of the chromatin and nuclear environment that play key roles in the ...
Jack Wootton, Evi Soutoglou
doaj   +1 more source

Global Properties of Nucleus–Nucleus Collisions [PDF]

open access: yes, 2009
In this lecture note, we discuss the global properties of nucleus-nucleus collisions. After a brief introduction to heavy-ion collisions, we introduce useful kinematics and then discuss the bulk hadron production in A+A collisions. At the end we discuss the hadronization and hadronic freeze-out in A+A collisions.
Raghunath Sahoo   +3 more
openaire   +3 more sources

Prognostic cellular senescence-related lncRNAs patterns to predict clinical outcome and immune response in colon cancer

open access: yesFrontiers in Immunology
BackgroundCellular senescence (CS) is believed to be a major factor in the evolution of cancer. However, CS-related lncRNAs (CSRLs) involved in colon cancer regulation are not fully understood.
Lichao Cao   +18 more
doaj   +1 more source

Mitonuclear Genetic Interactions in the Basidiomycete Heterobasidion parviporum Involve a Non-conserved Mitochondrial Open Reading Frame

open access: yesFrontiers in Fungal Biology, 2021
The mitochondrial and nuclear genomes of Eukaryotes are inherited separately and consequently follow distinct evolutionary paths. Nevertheless, the encoding of many mitochondrial proteins by the nuclear genome shows the high level of integration they ...
Pierre-Henri Clergeot, Åke Olson
doaj   +1 more source

Qs in the Nucleus [PDF]

open access: yesNeuron, 2001
The polyglutamine diseases include at least nine neurodegenerative disorders. Accumulation of mutant protein with a toxic gain-in function in the nucleus appears to be the pathological basis of these diseases. In this issue of Neuron, La Spada et al. (2001) provide insight into the cell specificity of pathology for a polyglutamine disease by relating ...
openaire   +3 more sources

Dispersive contribution to the nucleus-nucleus potential [PDF]

open access: yesPhysical Review C, 1987
With a simple parametrization of the empirical imaginary potential depths, the real potential induced by a dispersion relation is calculated analytically for the elastic scattering of O16 by several target nuclei. Between 25e50 % of the real potential empirical depths can be attributed to this dispersive contribution when the energy approaches the ...
openaire   +3 more sources

Oestrogen receptor beta isoform expression in sporadic colorectal cancer, familial adenomatous polyposis and progressive stages of colorectal cancer

open access: yesBMC Cancer, 2017
Background Among the sex hormones, oestrogen may play a role in colorectal cancer, particularly in conjunction with oestrogen receptor-β (ERβ). The expression of ERβ isoform variants and their correlations with familial adenomatous polyposis (FAP ...
Paulo Roberto Stevanato Filho   +11 more
doaj   +1 more source

Dynamic Virus-Dependent Subnuclear Localization of the Capsid Protein from a Geminivirus

open access: yesFrontiers in Plant Science, 2017
Viruses are intracellular parasites with a nucleic acid genome and a proteinaceous capsid. Viral capsids are formed of at least one virus-encoded capsid protein (CP), which is often multifunctional, playing additional non-structural roles during the ...
Liping Wang   +9 more
doaj   +1 more source

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