Results 91 to 100 of about 5,256,026 (319)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors
Journal of Immunology Research, 2022 Aims. To explore the expression of circular RNA (circRNA) in gastrointestinal stromal tumors. Background. Gastrointestinal stromal tumors (GIST) are mainly distributed in the stomach and small intestine.
null Chunyan-Zou +7 more
doaj +1 more source
Effective null Raychaudhuri equation
, 2018 The effects on Raychaudhuri's equation of an intrinsically-discrete or particle nature of spacetime are investigated. This is done through the consideration of null congruences emerging from, or converging to, a generic point of spacetime, i.e.
Pesci, Alessandro
core +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
Naked singularity resolution in cylindrical collapse
, 2006 In this paper, we study the gravitational collapse of null dust in the cylindrically symmetric spacetime. The naked singularity necessarily forms at the symmetry axis.
C. J. S. Clarke +8 more
core +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Protection of Religious Minorities under Islamic Legal System and International Law of Human Rights [PDF]
پژوهش تطبیقی حقوق اسلام و غرب, 2017 This article, through a descriptive-analytic method and on a library-based approach and by means of analyzing the protection of religious minorities under Islamic legal system in one side and International Minority Protection Law (IMPL) in the other side,
Mostafa Fazaeli +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
wiley +1 more source
Differentiation of the meaning of art in the Traditional and modern view from the Coomaraswamy Idea [PDF]
هنر اسلامی, 2018 Many thinkers consider art as a means to perceive the truth and it is the way to achieve the highest human knowledge and epistem, And a kind of epistem that access to it with other means and equipment is impossible.Coomaraswamy is one of the thinkers who
Reza Ali Pour +3 more
doaj +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source