Results 81 to 90 of about 1,701,182 (305)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
On the null-subject phenomenon [PDF]
, 2018 This chapter offers an up-to-date discussion of the multiple issues raised by the null-subjectt phenomenon and of the theoretical analyses put forth within Generative Grammar, situating the volume's chapters within current scholarship.
Cognola, Federica, Casalicchio, Jan
core +1 more source
Protection of Religious Minorities under Islamic Legal System and International Law of Human Rights [PDF]
پژوهش تطبیقی حقوق اسلام و غرب, 2017 This article, through a descriptive-analytic method and on a library-based approach and by means of analyzing the protection of religious minorities under Islamic legal system in one side and International Minority Protection Law (IMPL) in the other side,
Mostafa Fazaeli +2 more
doaj +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Singularities of null mean curvature flow of null hypersurfaces in Lorentzian manifolds
, 2019 We classify two main singularities, as type I and type II, associated with null mean curvature flow of screen conformal null hypersurfaces in Lorentzian manifolds.
Ssekajja, Samuel
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Interpreting null findings from trials of alcohol brief interventions
, 2014 The effectiveness of alcohol brief intervention (ABI) has been established by a succession of meta-analyses but, because the effects of ABI are small, null findings from randomized controlled trials are often reported and can sometimes lead to skepticism
Nick Heather +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
Publication Bias Against Null Results [PDF]
Studies suggest a bias against the publication of null (p > .05) results. Instead of significance, we advocate reporting effect sizes and confidence intervals, and using replication studies.
JS Armstrong, Raymond Hubbard
core