Results 61 to 70 of about 964,719 (311)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Families, Family Strengths and the Changing World
Journal of Family Strengths, 2015 Angelo P. Giardino, Robert Sanborn, William V. Flores and E. Christopher Lloyd discuss the latest issue of the Journal of Family Strengths.
null null +3 more
doaj +1 more source
Prioritizing of repair and rehabilitation for concrete bridges of road network in Khorasan Razavi province, using analytical hierarchy process (AHP) [PDF]
Journal of Structural and Construction Engineering, 2019 Considering the necessity of developing the road network, bridges as infrastructures, play a key role in helping and sustaining vital activities in the recovery phase after natural disasters and events.
Soheil Ghareh +2 more
doaj +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Gravitational action with null boundaries [PDF]
, 2016 The present paper provides a complete treatment of boundary terms in general relativity to include cases with lightlike boundary segments along with the usual spacelike and timelike ones.
L. Lehner +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Averaged null energy condition from causality [PDF]
Journal of High Energy Physics, 2016 Unitary, Lorentz-invariant quantum field theories in flat spacetime obey mi-crocausality: commutators vanish at spacelike separation. For interacting theories in more than two dimensions, we show that this implies that the averaged null energy, ∫ duTuu ...
Thomas Hartman +2 more
semanticscholar +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Koncepcja wielofunkcyjności jako element zrównoważonego rozwoju obszarów wiejskich
Polityki Europejskie, Finanse i Marketing, 2009 Opracowanie koncentruje się na prezentacji najważniejszych kwestii i kluczowych informacji dotyczących koncepcji wielofunkcyjnego rozwoju obszarów wiejskich.
Mieczysław Adamowicz +1 more
doaj +2 more sources