Results 61 to 70 of about 1,701,182 (305)
, 2020 Multiple modern programming languages, including Kotlin, Scala, Swift, and C#, have type systems where nullability is explicitly specified in the types. All of the above also need to interoperate with languages where types remain implicitly nullable, like Java. This leads to runtime errors that can manifest in subtle ways. In this paper, we show how to
Abel Nieto +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Strategien zur Null-Fehler-Produktion
, 2015 Die Null-Fehler-Produktion zählt heute zu den vorrangigsten Zielen eines jeden Unternehmens. Sie beeinflusst maßgeblich die Wertschöpfung des Unternehmens und stellt damit eine der wichtigsten Stellgrößen für eine nachhaltige Unternehmensstrategie dar ...
Schloske, Alexander
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Koncepcja wielofunkcyjności jako element zrównoważonego rozwoju obszarów wiejskich
Polityki Europejskie, Finanse i Marketing, 2009 Opracowanie koncentruje się na prezentacji najważniejszych kwestii i kluczowych informacji dotyczących koncepcji wielofunkcyjnego rozwoju obszarów wiejskich.
Mieczysław Adamowicz +1 more
doaj +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Invasion of Matrix Species in Small Habitat Patches
Ecology and Society, 1999 The diversity, expressed as species richness in equal-sized samples, of wood-living beetles in successional stages of deciduous forest after forest fires approximately 100 years ago did not differ between patch sizes in this study.
Stefan Ås
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source