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Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile+8 more
wiley +1 more source
Isatin-N-sulfonic acid as new, efficient and reusable catalyst for the synthesis of 2-Amido-alkyl-phenols under solvent-free conditions [PDF]
In this research, a simple and highly efficient method for the synthesis of 2-amidoalkyl phenols using isatin-N-sulfonic acid as a solid acidic catalyst has been reported.
محمدعلی زلفی گل+4 more
doaj +1 more source
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu+11 more
wiley +1 more source
The flexural behavior of multi-layer high performance self-compacting hybrid fibers concrete slabs [PDF]
Fiber concretes are a new type of composite material in the manufacturing industry, due to lack of information, identification behavioral characteristics requires laboratory studies.
Amirhosein Sahraei moghadam+2 more
doaj +1 more source
If all subsets of cardinality less than 2"o of the real line R are Lebesgue measurable then there exists a permutation p of R with p = p-' such that on the a-field generated by S U p(s) there is no continuous probability measure. 1. Let IS I denote the cardinality of the set S.
E. Grzegorek, C. Ryll-Nardzewski
openaire +2 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
wiley +1 more source
Students’ Achievement Motivation and factors Determining the Quality of Higher Education [PDF]
The purpose of this study was to investigate students’ achievement motivation according to factors determining the quality of higher education. A descriptive and correlation design was used for the research with data collected using questionnaire.
asghar zamani, mahtab pooratashi
doaj +1 more source
Null Subjects in Northeast English [PDF]
This paper presents data and analysis relating to null subjects in spoken colloquial English. While English is not a „pro-drop? language (i.e.
Bailey, Laura R.
core
On correlation functions of Wilson loops, local and non-local operators
We discuss and extend recent conjectures relating partial null limits of correlation functions of local gauge invariant operators and the expectation value of null polygonal Wilson loops and local gauge invariant operators. We point out that a particular
A Brandhuber+34 more
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source