Results 31 to 40 of about 18,908 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Average and Marginal Labour Values are: On Log (n)—A Reply to Hagendorf

World Review of Political Economy, 2014
The article discusses Hagendorf's contribution to the debate on average versus marginal labour costs as a metric of economic efficiency. It criticises his assumption of rising marginal costs and compares his position to that of other authorities.
Michael Reifferscheidt, Paul Cockshott
doaj   +1 more source

Pronouncement of Embedded Agency in the Field of Social Entrepreneurship [PDF]

Problemy Zarządzania, 2018
The paper provides insights into how social entrepreneurship and the institutional theory framework can be combined. The author situates the social entrepreneurship phenomenon here, and embarks on the traditional structure vs agency debate from social ...
Marzena Starnawska, PhD
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

How negative can null energy be in large N CFTs?

SciPost Physics
Smeared null energy has been shown to be bounded from below for free minimally coupled quantum field theories. This is not the case for conformally coupled free bosonic theories where states of unbounded null energy can be constructed by increasing the ...
Jackson R. Fliss, Ben Freivogel, Eleni-Alexandra Kontou, Diego Pardo Santos
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sluicing, Sprouting and Missing Objects

Studies in Chinese Linguistics, 2017
Taking “sluicing” to be derived by movement + deletion, as represented by Merchant (2001), and “pseudo-sluicing” to be a base-generated structure [pro (+be) + wh] (going by Wei 2004; Adams 2004), this paper reviews arguments for and against the presence ...
Li Yen-Hui Audrey, Wei Ting-Chi
doaj   +1 more source

Ainda a questão dos sujeitos pré-verbais em PE: uma resposta a Costa (2001) Pre-verbal subjects in EP: a reply to Costa (2001)

DELTA: Documentação de Estudos em Lingüística Teórica e Aplicada, 2006
Este artigo examina os argumentos de Costa 2001 contra a proposta de que os sujeitos não se elevam por movimento A para Spec-IP em Português Europeu (PE) e defende que nenhum deles infirma a referida proposta.
Pilar P. Barbosa
doaj   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source