Results 71 to 80 of about 1,713,872 (237)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Null-controllability of linear parabolic-transport systems [PDF]

, 2020
Over the past two decades, the controllability of several examples of parabolic-hyperbolic systems has been investigated. The present article is the beginning of an attempt to find a unified framework that encompasses and generalizes the previous results.
Armand Koenig, Beauchard, Karine, Koenig, Armand, Le Balc’h, Kévin, Karine Beauchard, Kévin Le Balc’h   +5 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Boundary Controllability of a Pseudoparabolic Equation

Abstract and Applied Analysis, 2013
We deal with the controllability problem for the pseudoparabolic equation by means of boundary controls. Due to the unusual spectrum of this kind of equations, we prove that the null controllability property is false.
Qiang Tao, Hang Gao, Zheng-an Yao
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Non null controllability of Stokes equations with memory [PDF]

, 2020
In this paper, we consider the null controllability problem for the Stokes equations with a memory term. For any positive final time T > 0, we construct initial conditions such that the null controllability does not hold even if the controls act on the ...
Fernández Cara, Enrique, F. Machado, José Lucas, Araujo de Souza, Diego   +2 more
core   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Uniform null controllability for parabolic equations with discontinuous diffusion coefficients

, 2021
In this article, we study the null-controllability of a heat equation in a domain composed of two media of different constant conductivities. In particular, we are interested in the behavior of the system when the conductivity of the medium on which the ...
Sylvain Ervedoza, Roberto Morales, Dardé, Jérémi, Ervedoza, Sylvain, Morales, Roberto, Jérémi Dardé   +5 more
core   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

A null controllability problem with a finite number of constraints on the normal derivative for the semilinear heat equation

Electronic Journal of Qualitative Theory of Differential Equations, 2012
We consider the semilinear heat equation in a bounded domain of $\mathbb{R}^m$. We prove the null controllability of the system with a finite number of constraints on the normal derivative, when the control acts on a bounded subset of the domain.
Carole Louis-Rose
doaj   +1 more source