Results 51 to 60 of about 1,713,872 (237)

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Controllability to trajectories of a Ladyzhenskaya model for a viscous incompressible fluid

Comptes Rendus. Mathématique, 2021
We consider the controllability of a viscous incompressible fluid modeled by the Navier–Stokes system with a nonlinear viscosity. To prove the controllability to trajectories, we linearize around a trajectory and the corresponding linear system includes ...
Guerrero, Sergio, Takahashi, Takéo
doaj   +1 more source

On the null-controllability of diffusion equations [PDF]

ESAIM: Control, Optimisation and Calculus of Variations, 2010
Summary: This work studies the null-controllability of a class of abstract parabolic equations. The main contribution in the general case consists in giving a short proof of an abstract version of a sufficient condition for null-controllability which has been proposed by Lebeau and Robbiano.
Tenenbaum, G, Tucsnak, Marius
openaire   +2 more sources

Boundary null controllability as the limit of internal controllability: The heat case

, 2020
It is well known that for the heat equation with Dirichlet boundary condition both internal and boundary null controllability hold with controls applied to any open subset of the domain and any open subset of the boundary, respectively.
Santos, Maurício Cardoso, J.-P. Puel, M.C. Santos, Puel, Jean Pierre, Chaves-Silva, Felipe Wallison, F.W. Chaves-Silva   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Exact null controllability, complete stabilizability and continuous final observability of neutral type systems

International Journal of Applied Mathematics and Computer Science, 2017
For abstract linear systems in Hilbert spaces we revisit the problems of exact controllability and complete stabilizability (stabilizability with an arbitrary decay rate), the latter property being related to exact null controllability.
Rabah Rabah, Sklyar Grigory, Barkhayev Pavel   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A deterministic criterion for approximate controllability of stochastic differential equations with jumps

Results in Applied Mathematics
This paper investigates the approximate controllability and approximate null controllability of a class of linear stochastic systems driven by Gaussian random measures.
Junfei Guo, Zhiyuan Huang, Rui Sun, Zhao Yikai   +3 more
doaj   +1 more source