Results 61 to 70 of about 418,792 (249)

An Efficient Null Model for Conformational Fluctuations in Proteins [PDF]

Structure, 2012
Protein dynamics play a crucial role in function, catalytic activity, and pathogenesis. Consequently, there is great interest in computational methods that probe the conformational fluctuations of a protein. However, molecular dynamics simulations are computationally costly and therefore are often limited to comparatively short timescales.
Harder, Tim, Borg, Mikael, Bottaro, Sandro, Boomsma, Wouter, Olsson, Simon, Ferkinghoff-Borg, Jesper, Hamelryck, Thomas   +6 more
openaire   +4 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Worldwide patterns in species richness of falconiformes: analytical null models, geometric constraints, and the mid-domain effect Padrões mundiais de riqueza de espécies de Falconiformes: modelos nulos analíticos, restrições geométricas e o efeito do domínio médio

Brazilian Journal of Biology, 2004
Recently, the hypothesis that the geographic distribution of species could be influenced by the shape of the domain edges, the so-called Mid-Domain Effect (MDE), has been included as one of the five credible hypotheses for explaining spatial gradients in
T. F. L.V. B. Rangel, J. A. F. Diniz-filho   +1 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Modeling: Neutral, Null, and Baseline [PDF]

Philosophy of Science, 2018
Two strategies for using a model as “null” are distinguished.Null modelingevaluates whether a process is causally responsible for a pattern by testing it against a null model.Baseline modelingmeasures the relative significance of various processes responsible for a pattern by detecting deviations from a baseline model.
openaire   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Aquatic insects in river of Andean relict of central Chilean native forest (Alto Huemul, 34°S, Chile) [PDF]

Brazilian Journal of Biology
The aquatic insects in Chilean inland waters included endemic species, as well as species widespread along South America, and their presence is related to the water quality of their inhabits habitats.
P. R. De los Rios-Escalante, M. A. Gonzalez-Arratia, A. Baaoloudj, J.G. Farias   +3 more
doaj   +1 more source

Propagule Pressure: A Null Model for Biological Invasions [PDF]

Biological Invasions, 2006
(Uploaded by Plazi for the IPBES Invasive Alien Species Assessment) Invasion ecology has been criticised for its lack of general principles. To explore this criticism, we conducted a meta-analysis that examined characteristics of invasiveness (i.e.
Colautti, Robert I., Grigorovich, Igor A., MacIsaac, Hugh J.   +2 more
openaire   +2 more sources

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Multiple assembly rules drive the co-occurrence of orthopteran and plant species in grasslands: combining network, functional and phylogenetic approaches

Frontiers in Plant Science, 2016
Understanding the factors underlying the co-occurrence of multiple species remains a challenge in ecology. Biotic interactions, environmental filtering and neutral processes are among the main mechanisms evoked to explain species co-occurrence.
Bertrand Fournier, Arnaud Mouly, François Gillet, François Gillet   +3 more
doaj   +1 more source