Results 51 to 60 of about 895,352 (296)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Post-Newtonian Gravitational Radiation and Equations of Motion via Direct Integration of the Relaxed Einstein Equations. I. Foundations [PDF]

, 2000
We present a self-contained framework called Direct Integration of the Relaxed Einstein Equations (DIRE) for calculating equations of motion and gravitational radiation emission for isolated gravitating systems based on the post-Newtonian approximation ...
A. Einstein, A. Einstein, A. Einstein, A. G. Wiseman, A. G. Wiseman, A. G. Wiseman, A. G. Wiseman, A. Papapetrou, A. S. Eddington, A. S. Eddington, B. R. Iyer, B. R. Iyer, C. Cutler, C. Cutler, C. M. Will, C. W. Misner, Clifford M. Will, E. Poisson, E. Poisson, H. Tagoshi, J. Ehlers, J. H. Taylor, J. H. Taylor, K. S. Thorne, K. S. Thorne, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. P. Grishchuk, M. Sasaki, M. Walker, M. Walker, M. Walker, Michael E. Pati, P. Jaranowski, P. Jaranowski, R. Epstein, R. V. Wagoner, S. Chandrasekhar, S. Chandrasekhar, S. Chandrasekhar, T. C. Quinn, T. Damour, T. Damour, T. Damour, T. Damour, T. Levi-Cività, V. Fock, W. de Sitter, W. de Sitter, W. L. Burke, Y. Mino, Y. Mino   +60 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Subject ellipsis in early child English

Ilha do Desterro, 2020
English-speaking children are known to omit subjects. Parametric analyses of the phenomenon have the advantage to give a simple answer to why children omit subjects and how they reach an adult grammar: the problem is reduced to a matter of parameter ...
Karina Bertolino
doaj   +1 more source

Null subjects in european and Brasilian Portuguese [PDF]

, 2005
The goals of this paper are twofold: a) to provide a structural account of the effects of the informal ‘Avoid Pronoun Principle’, proposed in Chomsky (1981: 65) for the Null Subject Languages (NSLs), and b) to compare, in European and Brazilian ...
Barbosa, Pilar, Duarte, Eugênia, Kato, Mary   +2 more
core  

Null Referential Subjects in Övdalian

Nordic Journal of Linguistics, 2010
This article is concerned with the description and analysis of Övdalian referential null subjects. A general background to Övdalian is provided together with the syntactic restrictions on the possible null subjects (wįð‘we’ andið‘you’). Interestingly, these null subjects in Övdalian do not appear in the same syntactic positions.
openaire   +2 more sources

Prediction Model for Etiologic Differentiation of Isolated Vestibular Syndrome in Emergency Settings

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to develop and validate a predictive model for differentiating central from peripheral etiologies in patients with isolated vestibular syndrome (VS). Methods In this multicenter retrospective cohort study, 506 patients with isolated VS from five hospitals were divided into derivation (n = 301) and validation (n = 205)
Guo Wenting, Du Liping, Yang Yi, Hu Jin, Ye Bijun, Wang Jianer, Liu Shuangsi, Guo Shunyuan, Cai Xiaofeng, Wang Huiyuan, Wu Bin, Yu Xiang, Shi Tianming   +12 more
wiley   +1 more source

A note on subject clitics in Akan

Studies in African Linguistics, 1998
This paper is concerned with the analysis of pronominal subject clitics (SCLs) in Akan within the Priniciples and Parameters framework of syntactic theory.
Richard Campbell
doaj   +3 more sources

Taraldsen’s generalization in diachrony : evidence from a diachronic corpus [PDF]

, 2016
International audienceWe present the first large scale quantitative investigation of the syncretisation of verbal subject agreement in Medieval French and test a classic analysis which relates non-syncretic agreement and null subjects as parts of the ...
Crabbé, Benoît, Prévost, Sophie, Simonenko, Alexandra   +2 more
core   +2 more sources