Results 21 to 30 of about 60,739 (260)

Bland–Altman Limits of Agreement from a Bayesian and Frequentist Perspective

open access: yesStats, 2021
Bland–Altman agreement analysis has gained widespread application across disciplines, last but not least in health sciences, since its inception in the 1980s.
Oke Gerke, Sören Möller
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Holographic approach to thermalization in general anisotropic theories

open access: yesJournal of High Energy Physics, 2021
We employ the holographic approach to study the thermalization in the quenched strongly-coupled field theories with very general anisotropic scalings including Lifshitz and hyperscaling violating fixed points.
Po-Chun Sun, Da-Shin Lee, Chen-Pin Yeh
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

O parâmetro Pro-drop e a aquisição de segunda língua

open access: yesSemina: Ciências Sociais e Humanas, 2011
Within the Government and Binding theory (GB), it is assumed the man is equipped with some innate language structure, Universal Grammar (UG), which contains a set of inviolable principles plus some open parameters which are set by experience.
Sonia Maria Lazzarini Cyrino
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

To Inflect or Not to Inflect Is the Question Indeed: Infinitives in Second Language (L2) Portuguese

open access: yesJournal of Portuguese Linguistics, 2007
In light of the predictions of two competing approaches to adult L2 acquisition – Full Access (FA) (e.g., White 1989, 2003; Schwartz & Sprouse 1996) and Failed Features (FF) (e.g., Hawkins & Chan 1997; Liceras & Díaz, 1999) – the present ...
Jason Rothman, Michael Iverson
doaj   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Information structure, subject positions, and the cartography of the preverbal field in Cibaeño Dominican Spanish

open access: yesIsogloss
Early generative studies on grammatical subjects produced two key findings: the Extended Projection Principle (Chomsky, 1982), and the Null Subject Parameter (NSP, e.g.
Timothy Gupton
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

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