Results 31 to 40 of about 5,459,792 (293)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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Null Subjects in Northeast English [PDF]
, 2011 This paper presents data and analysis relating to null subjects in spoken colloquial English. While English is not a „pro-drop? language (i.e.
Bailey, Laura R.
core
Bland–Altman Limits of Agreement from a Bayesian and Frequentist Perspective
Stats, 2021 Bland–Altman agreement analysis has gained widespread application across disciplines, last but not least in health sciences, since its inception in the 1980s.
Oke Gerke, Sören Möller
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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Holographic approach to thermalization in general anisotropic theories
Journal of High Energy Physics, 2021 We employ the holographic approach to study the thermalization in the quenched strongly-coupled field theories with very general anisotropic scalings including Lifshitz and hyperscaling violating fixed points.
Po-Chun Sun, Da-Shin Lee, Chen-Pin Yeh
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Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
O parâmetro Pro-drop e a aquisição de segunda língua
Semina: Ciências Sociais e Humanas, 2011 Within the Government and Binding theory (GB), it is assumed the man is equipped with some innate language structure, Universal Grammar (UG), which contains a set of inviolable principles plus some open parameters which are set by experience.
Sonia Maria Lazzarini Cyrino
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
To Inflect or Not to Inflect Is the Question Indeed: Infinitives in Second Language (L2) Portuguese
Journal of Portuguese Linguistics, 2007 In light of the predictions of two competing approaches to adult L2 acquisition – Full Access (FA) (e.g., White 1989, 2003; Schwartz & Sprouse 1996) and Failed Features (FF) (e.g., Hawkins & Chan 1997; Liceras & Díaz, 1999) – the present ...
Jason Rothman, Michael Iverson
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
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