Results 21 to 30 of about 184,404 (262)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Rank Order of Accurate Use at the Syntax-Pragmatics Interface: Evidence from French and Spanish L2 Acquisition

Linguistik Online, 2011
In an attempt to investigate the vulnerability of the syntax-pragmatics interface and to shed light on the acquisition of subjects and objects in two different languages, namely the [+null subject] language Spanish and the [-null subject] language French,
Nicola Work
doaj   +1 more source

Glutathione S-transferase M1 and T1 genes deletion polymorphisms and risk of developing essential hypertension: a case-control study in Burkina Faso population (West Africa)

BMC Medical Genetics, 2020
Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks factors that may be associated with many types of disease processes such as cancer, diabetes, and ...
Herman Karim Sombié, Abel Pegdwendé Sorgho, Jonas Koudougou Kologo, Abdoul Karim Ouattara, Sakinata Yaméogo, Albert Théophane Yonli, Florencia Wendkuuni Djigma, Daméhan Tchelougou, Dogfounianalo Somda, Isabelle Touwendpoulimdé Kiendrébéogo, Prosper Bado, Bolni Marius Nagalo, Youssoufou Nagabila, Enagnon Tiémoko Herman Donald Adoko, Patrice Zabsonré, Hassanata Millogo, Jacques Simporé   +16 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Body-anchored verbs and argument omission in two sign languages

Glossa, 2019
Using quantitative methods, we analyze naturalistic corpus data in two sign languages, German Sign Language and Russian Sign Language, to study subject-omission patterns. We find that, in both languages, the interpretation of null subjects depends on the
Marloes Oomen, Vadim Kimmelman
doaj   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

When Contrast Overrides Animacy: Overt Personal Pronouns as Subjects in Anaphoric Contexts in Adult Romanian

Catalan Journal of Linguistics
The current study investigates how adult Romanian speakers choose between overt and null pronoun subjects in inter-sentential anaphoric contexts, and how their choices are shaped by two interacting factors: contrast and animacy.
Adina Camelia Bleotu, Ekaterina Levina
doaj   +1 more source

Remarks on Finite Control and Hyper-Raising in Brazilian Portuguese

Journal of Portuguese Linguistics, 2019
In this reply I examine Modesto’s (2011) claim that null subjects in Brazilian Portuguese (BP) are not controlled and are not derived by movement.
Jairo Nunes
doaj   +2 more sources

What May Statistics Tell Us About Null Subjects in Russian?

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2022
The article highlights the linguistic phenomenon of abandoning the expletively presented syntactic subject (the Null Subject Phenomenon) in different languages and focuses on its exemplification by the Russian language.
Polina Eismont
doaj   +1 more source