Results 31 to 40 of about 184,404 (262)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Variation in the use and interpretation of null subjects: A view from Greek and Italian

Glossa, 2020
We aim to understand whether Greek and Italian, two null subject languages, differ in the use and interpretation of null subjects, based on evidence from both a production and a comprehension experiment.
Christiane M. Bongartz, Jacopo Torregrossa, Maria Andreou   +2 more
doaj   +2 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

3SG null subjects in Brazilian Portuguese/Spanish grammars

Isogloss
I revisit some ‘old’ issues in Second Language Acquisition concerning Markedness and the Subset Principle (Berwick 1985; Wexler and Manzini 1987) in a parametric hierarchy approach (Roberts 2019) to analyze null subjects in Spanish/BP grammars.
Samara Almeida
doaj   +1 more source

Null Subject Occurrence in Monolingual Spanish SLI: A Discriminant Function Analysis

Languages, 2018
Background: Child Spanish-speakers appear to use more null subjects than do adults. Null subject use, like the use of tense marking, is sensitive to discourse-pragmatics.
John Grinstead, Paij Lintz, Amy Pratt, Mariana Vega-Mendoza, Juliana De la Mora, Myriam Cantú-Sánchez, Blanca Flores-Avalos   +6 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Spanish null subjects: descriptive and analytical issues

Borealis: An International Journal of Hispanic Linguistics
The goal of this article is to present a detailed overview of the empirical patterns concerning null subjects in Spanish, and the theories that have been proposed to account for them.
Antonio Fábregas
doaj   +1 more source

Dominican 'ello' as a non-deleted null expletive

Borealis: An International Journal of Hispanic Linguistics, 2014
The Spanish variety spoken in the dominican region of El Cibao (DSEC) has an expletive pronoun ello which is optative and seems to be devoid of any semantic value.
Carlos Muñoz Pérez
doaj   +1 more source

Utility of Integrated Analysis of Pharmacogenomics and Pharmacometabolomics in Early Phase Clinical Trial: A Case Study of a New Molecular Entity [PDF]

Genomics & Informatics, 2018
In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a
Jaeseong Oh, Sojeong Yi, Namyi Gu, Dongseong Shin, Kyung-Sang Yu, Seo Hyun Yoon, Joo-Youn Cho, In-Jin Jang   +7 more
doaj   +1 more source