Results 41 to 50 of about 6,193 (294)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The inverse nullity pair problem and the strong nullity interlacing property

open access: yes, 2023
The inverse eigenvalue problem studies the possible spectra among matrices whose off-diagonal entries have their zero-nonzero patterns described by the adjacency of a graph $G$.
Flagg, Mary   +5 more
core  

Nullity of contrcts for lifelong support

open access: yes, 2023
Problem ugovora o dosmrtnom uzdržavanju jedna je od najaktualnijih tema u Republici Hrvatskoj. Mnogi pojedinci su prevareni ovakvim vrstama ugovora, iako je njihov cilj bio pomoći najranjivijima među nama.
Vlahov, Vice
core   +2 more sources

El alcance del control judicial de la inadmisión de la acción de nulidad; a propósito de la Sentencia del TS de 1 de diciembre de 2020

open access: yesRevista Vasca de Administración Pública, 2021
This comment approaches the most controversial facets of the invalidity action of administrative acts. It is particularly focused on the admission process of the invalidity action, and on the scope of the limits of the review of administrative acts ...
Carmen Agoués Mendizabal
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

On the nullity of bicyclic graphs

open access: yes, 2008
The nullity of a graph is the multiplicity of the eigenvalue zero in its spectrum. In this paper, we obtain the nullity set of bicyclic graphs of order n, and determine the bicyclic graphs with maximum ...
Liu, Bolian   +2 more
core   +1 more source

On The Nullity of Generalized Rooted T-Tuple With B-Bridge Coalescence Graphs

open access: yesScience Journal of University of Zakho, 2016
In this paper, we determine the nullity of generalized rooted t-tuple coalescence graphs and the nullity of generalized rooted t-tuple with b-bridge coalescence graphs. Finally, the nullity of generalized rooted t-tuple with b-path coalescence graph and (
Nechirvan B. Ibrahim
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

Reflection on Option for Delayed Payment of the Price [PDF]

open access: yesآموزه‌‌های فقه مدني, 2020
Option is one of the most important causes of dissolution of contracts, which has various types in the jurisprudence of Islamic religions and legal systems of the world.
Ali Nosrati
doaj  

Home - About - Disclaimer - Privacy