Results 71 to 80 of about 6,193 (294)
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
, 2023 U ovom radu obrađena je tema ništetnih pravnih poslova. Uz pobojne, predstavljaju oblik nevaljanih pravnih poslova. Glavna je značajka ništetnih pravnih poslova ta da ne proizvode pravne učinke koje bi proizvodili da su valjani.
Defrančeski, Marta
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
, 2009 Jurisprudence provides a number of definitions for Nullity. One of these definitions is that it is a legal or penal system aimed at protecting the legal rules for establishing criminal ...
Allen, Andrew
core
Existence of Regular Nut Graphs for Degree at Most 11
Discussiones Mathematicae Graph Theory, 2020 A nut graph is a singular graph with one-dimensional kernel and corresponding eigenvector with no zero elements. The problem of determining the orders n for which d-regular nut graphs exist was recently posed by Gauci, Pisanski and Sciriha.
Fowler Patrick W. +4 more
doaj +1 more source
Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler +20 more
wiley +1 more source
On the nullity of tricyclic graphs
, 2011 The nullity of a graph G, denoted by η(G), is the multiplicity of the eigenvalue zero in its spectrum. It is known that η(G)⩽n-2 if G is a simple graph on n vertices and G is not isomorphic to nK1.
Bolian Liu +3 more
core +1 more source
, 2018 završnom radu je prikazana tema ništetnosti pravih poslova. Definirana je ništetnost kao jedan od oblika nevaljanih pravnih poslova. Uz pobojnost, ništetnost predstavlja oblik nevaljanih pravnih poslova.
Pavić, Vesna
core +1 more source