Results 111 to 120 of about 3,259,448 (285)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

A Fourier transform differentiator operator

open access: yesResults in Physics
By utilizing the Fourier transform, we present a practical method for evaluating a function of a derivative applied to any other arbitrary function of a single complex variable.
Blanca L. Moreno-Ley   +3 more
doaj   +1 more source

Hilbert's Tenth Problem for function fields of varieties over number fields and p-adic fields

open access: yesJournal of Algebra, 2007
Let k be a subfield of a p-adic field of odd residue characteristic, and let L be the function field of a variety of dimension n >= 1 over k. Then Hilbert's Tenth Problem for L is undecidable. In particular, Hilbert's Tenth Problem for function fields of varieties over number fields of dimension >= 1 is undecidable.
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Superstrong Magnetic Fields in Sunspot Bipolar Light Bridges

open access: yesThe Astrophysical Journal Letters
Recent solar observations of bipolar light bridges (BLBs) in sunspots have, in a few individual cases, revealed magnetic fields up to 8.2 kG, which is at least twice as strong as typical values measured in sunspot umbrae.
J. S. Castellanos Durán   +4 more
doaj   +1 more source

General Aspects of Line Shapes in Plasmas in the Presence of External Electric Fields

open access: yesAtoms
The present paper discusses a number of topics relevant to line broadening in the presence of periodic oscillatory fields. Specifically, we discuss the applicablility of the expression usually employed to compute the autocorrelation function, the ...
Spiros Alexiou
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Cylotomic function fields over finite fields with class number three

open access: yes, 2019
We list all subfields of cyclotomic function fields over rational function fields with class number three. We also determine all the imaginary abelian extensions with relative class number three, explicitly.
Bilhan, Mehpare   +2 more
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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