Results 151 to 160 of about 11,325,403 (303)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Heights on elliptic curves over number fields, period lattices, and complex elliptic logarithms [PDF]
This thesis presents some major improvements in the following computations: a lower bound for the canonical height, period lattices, and elliptic logarithms.
Thongjunthug, Thotsaphon
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Margulis numbers and number fields
, 2009 This is a completely new paper. Many of the results of my previously posted paper of the same title were subsumed by my paper "A generic Margulis number for hyperbolic 3-manifolds." In the new paper I get a considerably stronger generic Margulis number for the class of manifolds with a prescribed trace field than for the class of all (closed ...
openaire +2 more sources
Death certificate: Mrs. Cora Fields
, 1917 This is a photograph of the death certificate for Mrs. Cora Fields, deceased on 1917-09-07, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed.
Ruebel Funeral Home (Little Rock, Ark.)
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Death certificate: Fred Fields
, 1917 This is a photograph of the death certificate for Fred Fields, deceased on 1917-12-24, filed with the Arkansas Department of Health by the Ruebel Funeral Home in Little Rock.Transcribed.
Ruebel Funeral Home (Little Rock, Ark.)
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