Results 91 to 100 of about 380,680 (312)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Tied Free-Field boundaries to enhance numerical accuracy of earthquake simulations

open access: yesFrontiers in Built Environment
Free-Field (FF) boundaries have previously been developed to replicate the (infinite) far-free-field domain in the simulation of earthquake loading problems.
J. León González Acosta   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Direct numerical simulation of turbulent flow past a trailing edge and the associated noise generation

open access: yes, 2008
Direct numerical simulations (DNS) are conducted of turbulent flow passing an infinitely thin trailing edge (TE). The objective is to investigate the turbulent flow field in the vicinity of the TE and the associated broadband noise generation.
Sandberg, Richard D., Sandham, Neil D.
core   +1 more source

Exact and approximate solutions of Riemann problems in non-linear elasticity [PDF]

open access: yes, 2009
Eulerian shock-capturing schemes have advantages for modelling problems involving complex non-linear wave structures and large deformations in solid media.
Barton, Philip Trevor   +3 more
core   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

A Modified Three-Level Average Linear-Implicit Finite Difference Method for the Rosenau-Burgers Equation

open access: yesAdvances in Mathematical Physics, 2014
We introduce a new technique, a three-level average linear-implicit finite difference method, for solving the Rosenau-Burgers equation. A second-order accuracy on both space and time numerical solution of the Rosenau-Burgers equation is obtained using a ...
Jiraporn Janwised   +3 more
doaj   +1 more source

Intra-procedural Optimization of the Numerical Accuracy of Programs [PDF]

open access: yes, 2015
Numerical programs performing floating-point computations are very sensitive to the way formulas are written. These last years, several techniques have been proposed concerning the transformation of arithmetic expressions in order to improve their accuracy and, in this article, we go one step further by automatically transforming larger pieces of code ...
Nasrine Damouche   +2 more
openaire   +2 more sources

Development of a rotor model for the numerical simulation of helicopter exterior flow-fields

open access: yes, 2004
Includes bibliographical references (leaves 84-85).A numerical methodology is developed to model the effect of a rotor on the surrounding flow-field. The model calculates the time-averaged aerodynamic forces exerted on the air by the fan blades within ...
Hotchkiss, Paul
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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