Results 71 to 80 of about 380,680 (312)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Study of total variation diminishing (TVD) slope limiters in dam-break flow simulation

Water Science and Engineering, 2018
A two-dimensional (2D) dam-break flow numerical model was developed based on the finite-volume total variation diminishing (TVD) and monotone upstream-centered scheme for conservation laws (MUSCL)-Hancock scheme, which has second-order accuracy in both ...
Feng-peng Bai, Zhong-hua Yang, Wu-gang Zhou   +2 more
doaj   +1 more source

Numerical analysis of time-dependent Boussinesq models [PDF]

, 1990
In this paper we analyse numerical models for time-dependent Boussinesq equations. These equations arise when so-called Boussinesq terms are introduced into the shallow water equations.
J. Mooiman, Wubs, F.W.,, Houwen, Piet, Mooiman, J., F. W. Wubs, Houwen, P.J. (Piet) van der, Wubs, F.W., Houwen, P.J. van der,, Mooiman, J.,, Houwen, P.J. van der, Wubs, Fred, P. J. van der Houwen, Wubs, F.W.; id_orcid, Wubs, F.W. (Fred)   +13 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Enhancing Accuracy and Numerical Stability for Repetitive Time-Varying System Identification: An Iterative Learning Approach

IEEE Access, 2020
Time-varying system identification is an appealing but challenging research area. Existing identification algorithms are usually subject to either low estimation accuracy or bad numerical stability.
Fazhi Song, Yang Liu, Xianli Wang, Wen Jin, Li Li   +4 more
doaj   +1 more source

Simplified numerical approach for incremental sheet metal forming process [PDF]

, 2014
The current work presents a finite element approach for numerical simulation of the incremental sheet metal forming (ISF) process, called here ‘‘ISF-SAM’’ (for ISF-Simplified Analysis Modelling).
BATOZ, Jean-Louis, DELAMEZIERE, Arnaud, BEN AYED, Lanouar, NOUARI, Mohammed, ROBERT, Camille   +4 more
core   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

A comparative study of immersed-boundary interpolation methods for a flow around a stationary cylinder at low Reynolds number [PDF]

, 2013
The accuracy and computational efficiency of various interpolation methods for the implementation of non grid-confirming boundaries is assessed. The aim of the research is to select an interpolation method that is both efficient and sufficiently accurate
Wissink, J, Bahai, H, Madani, Seyed Hossein, Wissink, Jan, Madani, SH, Bahai, Hamid   +5 more
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source