Results 31 to 40 of about 11,335,082 (272)

Evolving temporal association rules with genetic algorithms [PDF]

, 2010
A novel framework for mining temporal association rules by discovering itemsets with a genetic algorithm is introduced. Metaheuristics have been applied to association rule mining, we show the efficacy of extending this to another variant - temporal ...
Gongora, Mario A., Matthews, Stephen G., Stephen G. Matthews, Hopgood, Adrian, Hopgood, Adrian A., Adrian A. Hopgood, Mario A. Gongora   +6 more
core   +1 more source

Web Usage Mining with Evolutionary Extraction of Temporal Fuzzy Association Rules [PDF]

, 2013
In Web usage mining, fuzzy association rules that have a temporal property can provide useful knowledge about when associations occur. However, there is a problem with traditional temporal fuzzy association rule mining algorithms. Some rules occur at the
Gongora, Mario A., Matthews, Stephen G., Gongora, Mario Augusto, Hopgood, Adrian, Hopgood, Adrian A., Ahmadi, Samad   +5 more
core   +1 more source

Rule pruning and prediction methods for associative classification approach in data mining [PDF]

Recent studies in data mining revealed that Associative Classification (AC) data mining approach builds competitive classification classifiers with reference to accuracy when compared to classic classification approaches including decision tree and rule ...
Abu Mansour, Hussein Y
core   +3 more sources

Mining Numeric Association Rules with Genetic Algorithms

, 2001
In this last decade, association rules are being, inside Data Mining techniques, one of the most used tools to find relationships among attributes of a database. Numerous scopes have found in these techniques an important source of qualitative information that can be analyzed by experts in order to improve some aspects in their environment.
Mata Vázquez, Jacinto, Álvarez Macías, José Luis, Riquelme Santos, José Cristóbal   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A new rule pruning text categorisation method [PDF]

, 2010
Associative classification integrates association rule and classification in data mining to build classifiers that are highly accurate than that of traditional classification approaches such as greedy and decision tree.
Hadi, Wa'el, McCluskey, T.L., L. McCluskey, McCluskey, L., Hadi, Wa’el, Fadi Thabtah, Hussein Abu-Mansour, Wa'el Hadi, Thabtah, Fadi, Abu-Mansour, Hussein   +9 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Profile-based assessment of diseases affective factors using fuzzy association rule mining approach: A case study in heart diseases

Journal of Biomedical Informatics, 2021
The existing data mining solutions to identify risk factors associated with diseases are burdened with quite a few shortcomings. They usually use crisp partitions for numerical features and also do not use patient-specific profiles.
Ali Yavari, Amir Rajabzadeh, F. Mohammadi   +2 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source