Results 141 to 150 of about 476,485 (301)
Interfaces in Numerical Relativistic hydrodynamics
, 2010 This thesis investigates numerical techniques for modelling sharp interfacesbetween relativistic fluids. The motivation for this work lies in obtaining accuratemodels of neutron star interiors for use in multidimensional simulationsin general relativity.
Millmore, Stephen Timothy
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
THE DECISION OF PROBLEMS WITH UNILATERAL CONSTRAINTS AND CULON'S FRICTION UNDER THE DYNAMIC LOAD
Structural Mechanics of Engineering Constructions and Buildings, 2011 The numerical approach to the decision of dynamic problems with unilateral constraints and Culon's friction is offered. The decision is formulated on the basis of step-by-step analysis (in time) method with use of frame contact finite elements.
A A Lukashevich
doaj
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Numerical mathematics and advanced applications
, 2004 The book is the Proceedings of the Conference ENUMATH 2003, the 5th European Conference on Numerical Mathematics, concerned with most recent achievements in scientific computing, computational mathematics, numerical analysis and their applications. These
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On a Preloaded Compliance System of Fractional Order: Numerical Integration
In this paper, the use of a class of fractional-order dynamical systems with discontinuous right-hand side defined with Caputo’s derivative is considered. The existence of the solutions is analyzed.
Marius-F. Danca
core +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Qualitative analysis and numerical simulation of ABC fractional impulsive differential systems with implicit nonlinear terms and integral boundary conditions. [PDF]
PLoS OneSharif AA, Hamood M, Ghadle KP.
europepmc +1 more source