Results 121 to 130 of about 476,485 (301)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
, 1976 A general numerical method is described for the solution of linear elliptic and parabolic partial differential equations in the presence of boundary singularities.
Furzeland, RM, Crank, J
core
Numerical solutions of Cauchy integral equations and applications
, 1987 This thesis investigates the polynomial collocation method for the numerical solution of Cauchy type integral equations and the use of those equations and the related numerical techniques to solve two practical problem in Acoustics and Aerodynamics ...
Cuminato, José Alberto. +1 more
core +1 more source
Numerical methods in simulation of resistance welding [PDF]
, 2015 Finite element simulation of resistance welding requires coupling betweenmechanical, thermal and electrical models. This paper presents the numerical models and theircouplings that are utilized in the computer program SORPAS.
Zhang, Wenqi +5 more
core
A Method to Study Complex Enzyme Kinetics Involving Numerical Analysis of Enzymatic Schemes. The Mannitol Permease of Escherichia coli as an Example [PDF]
, 1993 An analysis of complex kinetic mechanisms is proposed that consists of two steps, (i) building of an kinetic scheme from experimental data other than steady-state kinetics and (ii) numerical simulation and analysis of the kinetics of the proposed scheme ...
Lolkema, Juke S.,, Lolkema, Juke S.
core
Numerical continuation of canard orbits in slow-fast dynamical systems
, 2009 A trajectory of a system with two clearly separated time scales generally consists of fast segments (or jumps) followed by slow segments where the trajectory follows an attracting part of a slow manifold. The switch back to fast dynamics typically occurs
Desroches, MF, Osinga, HM, Krauskopf, B
core +1 more source
Bargaining under incomplete information: a numerical example
, 1974 Selten R. Bargaining under incomplete information: a numerical example. Working Papers. Institute of Mathematical Economics. Vol 20.
Selten, Reinhard
core