Results 151 to 160 of about 270,289 (306)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Prenatal Testosterone Exposure and Numerical Competence in Children and Adults
The present thesis sought to investigate the potential relationship between the second to fourth finger ratio (2D:4D), as a somatic marker of prenatal testosterone exposure, and basic numerical skills in children and adults.
Brookes, Helen
core
Steady and unsteady simulation of Aerostabil windtunnel experiments
, 2011 CFD-CSMcoupled simulations of the 2001/2002 Aerostabil windtunnel experiments, making use of a beam finite element model and RANS computations have not agreed satisfyingly with the experimental data.
Stickan, Bernd, Dillinger, Johannes
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
, 2010 We consider the formation of machine background induced by proton losses in the long straight section of the LHCb experiment at LHC. Both sources showering from the tertiary collimators located in the LHCb insertion region as well as local beam-gas ...
Lieng, M H +7 more
core
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
How Can We Understand Numerical Cognition via Sensorimotor System: The Specific Role of Pointing [PDF]
openNumerous studies show that sensorimotor interactions with the environment facilitate the acquisition of numerical abilities. The present study investigated how grasping and pointing actions impact performance on subsequent numerical tasks, focusing ...
KARADENIZ, CEMRE
core