Results 131 to 140 of about 270,289 (306)

Numerical evaluation of rheological experiment

, 2012
A viscoelastic simply supported rotationally symmetric body, fixed on a base, is considered. The body is loaded by a flat plunger, which moves in the direction of the z axis by a constant velocity v. In this work the reaction force is computed.
Matoušek, Ivo, Salač, Petr
core  

Quantum gate identification: Error analysis, numerical results and optical experiment

, 2019
The identification of an unknown quantum gate is a significant issue in quantum technology. In this paper, we propose a quantum gate identification method within the framework of quantum process tomography.
Wang, Y, Dong, D, Qi, B, Yin, Q, Hou, Z, Yonezawa, H, Xiang, GY, Petersen, IR   +7 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Numerical Investigations of the Effects of Sidewall Compression and Relaminarization in 3D Scramjet Inlet

, 2011
This paper presents the numerical simulations and performance analysis of a 3D scramjet inlet with focus on the effects of sidewall compression and relaminarization. A well-validated finite volume flow solver was used to simulate a scramjet inlet with a
Marek Behr, Ali Gülhan, Hohn, Oliver, Gülhan, Ali, Birgit Reinartz, Tue Nguyen, Oliver Hohn, Behr, Marek, Reinartz, Birgit, Nguyen, Tue   +9 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

NUMERICAL SIMULATION OF THE WEISSENBERG EFFECT

, 2015
Weissenberg effect, or Rob-Climbing experiment, is encountered in many important industrial applications involving mixing process. In this experiment we insert a rotating rod into a container with viscoclastic fluid.
Oishi, Cassio M. [UNESP], Cerrolaza, M., Coutinho, A., Cruchaga, M., Figueiredo, Rafael A., Lew, A., Idelsohn, SR, Cuminato, Jose A., Sonzogni, V   +8 more
core  

Curves of shear stress-displacement of experiment and numerical simulation

, 2015
Curves of shear stress-displacement of experiment and numerical ...
Jianyun Chen (725586), Jing Li (10611), Qiang Xu (71522), Chunfeng Zhao (320370), Chenyang Yuan (725587)   +4 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

An Integrated DEM–FEM Simulation Framework for Preferential Flow Path Evaluation in Waste Landfill Composed of Non-Spherical Particles

Applied Sciences
A numerical experimental method combining the discrete element method (DEM) and the finite element method (FEM) is proposed to analyze water channel flow in heterogeneous porous media such as landfill layers.
Hiroyuki Ishimori, Kazuto Endo, Masato Yamada   +2 more
doaj   +1 more source