Results 121 to 130 of about 270,289 (306)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Testing construct validity of verbal versus numerical measures of preference uncertainty in contingent valuation

open access: yes
The numerical certainty scale (NCS) and polychotomous choice (PC) methods are two widely used techniques for measuring preference uncertainty in contingent valuation (CV) studies.
Bennett, Jeffrey W., Akter, Sonia
core  

Loading schematic diagram of the arch at numerical experiment.

open access: yes, 2018
Loading schematic diagram of the arch at numerical experiment.
Yingcheng Luan (4856668)   +4 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Accuracy of Numerical Solution to Dynamic Programming Models

open access: yes
Dynamic programming models with continuous state and control variables are solved approximately using numerical methods in most applications. We develop a method for measuring the accuracy of numerical solution of stochastic dynamic programming models ...
Lohano, Heman D., King, Robert P.
core  

Investigation and modelling of large scale cratering events : Lessons learnt from experimental analysis

open access: yes, 2011
Initiated as part of the 2010 Spin Your Thesis campaign, a new ESA Education programme, a group from the University of Glasgow Space Advanced Research Team successfully conducted a series of impact cratering experiments under a highly accelerated ...
Vasile, Massimiliano   +2 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Modeling the penetration of oscillating impulse electromagnetic fields through the screen, made of superconducting materials with time dispersion1

open access: yesInformatika, 2019
A procedure of simulating the processes of impulse oscillating TE-polarized plane electromagnetic fields penetration through the superconducting thin-shelled plane screen is developed.
V. T. Erofeenko, V. F. Bondarenko
doaj  

Numerical experiment schemes performed in the present study.

open access: yes, 2016
Numerical experiment schemes performed in the present study.
Abolghasem Akbari (760801)   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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