Results 101 to 110 of about 270,289 (306)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Assessment of strain measurement techniques to characterise mechanical properties of structural steel

Engineering Science and Technology, an International Journal, 2014
Strain measurement is important in mechanical testing. A wide variety of techniques exists for measuring strain in the tensile test; namely the strain gauge, extensometer, stress and strain determined by machine crosshead motion, Geometric Moire ...
H.B. Motra, J. Hildebrand, A. Dimmig-Osburg   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lavish Returns on Cheap Talk: Non-binding Communication in a Trust Experiment [PDF]

We let subjects interact with anonymous partners in trust (investment) games with and without one of two kinds of pre-play communication: numerical (tabular) only, and verbal and numerical.
Avner Ben-Ner, Ting Ren, Louis Putterman
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Vulnerable Option Pricing Under the 4/2 Stochastic Volatility Model

Axioms
In this paper, we study the pricing of vulnerable options, which are exposed to the option issuer’s default risk. We develop a pricing framework that integrates a reduced-form model for default risk with the 4/2 stochastic volatility model for the ...
Geonwoo Kim
doaj   +1 more source

Properties and classification of residual soils derived from Cambrian and Ordovician limestones and dolomites in southwestern Virginia

, 1985
Profiles of residual soils developed in materials weathered from limestones and dolomites in Washington, Smyth, Wythe, Roanoke, Botetourt, and Rockbridge Counties were characterized in order (i) to evaluate differences in distributions of soils related ...
Rector, Dean D., Edmonds, William J.
core  

A numerical study of strained three-dimensional wall-bounded turbulence

, 2000
Channel flow, initially fully developed and two-dimensional, is subjected to mean strains that emulate the effect of rapid changes of streamwise and spanwise pressure gradients in three-dimensional boundary layers, ducts, or diffusers.
Coleman, G.N., Spalart, P.R., Kim, J.
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

CRIOTHERMOAPPLICATIONAL THERAPY IN NEUROLOGY WITH THE USE OF THERMOELECTRIC ENERGY CONVERTERS

Вестник Дагестанского государственного технического университета: Технические науки, 2016
Aim. The etiology of neurological diseases caused by stress situations and other signs of technological progress is analyzed.Methods. The methods of physical therapy effects on the human body used in therapeutic neurology, which are of high priority ...
T. A. Ismailov, M. A. Hazamova, T. A. Ragimova   +2 more
doaj   +1 more source