Results 241 to 250 of about 473,529 (307)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

3D Simulation Study for a Pneumatic Nozzle-Cylindrical Flapper System. [PDF]

Sensors (Basel)
Xu P, Inaba K, Kagawa T.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Multiphase horizontal migration of BTEX in aquifers during in-situ oil shale exploitation. [PDF]

Sci Rep
Qingyu L, Hao W, Jiqing L, Shuya H, Zongming X, Rachel M.   +5 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Finite-Element Analysis of the Quasi-Static Response of Concrete Specimens Containing Polymeric Self-Healing Microcapsules. [PDF]

Polymers (Basel)
Zhelyazov T.
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Global optimization tailored for graphics processing units: Complete and rigorous search for large-scale nonlinear minimization. [PDF]

PNAS Nexus
Zhang G, Shan Q, Cagan J.
europepmc   +1 more source

Dipolar Order Mapping Based on Spin-Lock Magnetic Resonance Imaging. [PDF]

NMR Biomed
Gao Z, Shan Q, Zhou Z, Yu Z, Chen W.
europepmc   +1 more source

A phase-field model for vesicle membranes incorporating area-difference elasticity. [PDF]

PLoS Comput Biol
Liang Y, Celiker E, Lin P.
europepmc   +1 more source