Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Development of Design-Phase Digital Twin for Structural Optimization of a Biomedical Device. [PDF]
Pinol TR, Prentice LH, Fox K, Pang TY.
europepmc +1 more source
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas +6 more
wiley +1 more source
High-accuracy pseudospectral scheme for fractional diffusion-wave problems based on cardinal functions. [PDF]
Saray BN +5 more
europepmc +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source
Multiscale Shakedown Capacity Prediction of Parameterized Lattices Under Biaxial Loading Using Ensemble Learning. [PDF]
Wang L, Yuan H, Yuan W.
europepmc +1 more source
Transport Characteristics and Parametric Sensitivity of a Single-Stage Circular-Channel Knudsen Pump. [PDF]
Zhang D +4 more
europepmc +1 more source
An Adaptive Coupling of Edge-Based Smoothed FEM and SPH with a Bidirectional Element-Particle Transformation Algorithm for Laser Powder Bed Fusion. [PDF]
Suo M, Long T.
europepmc +1 more source
Artificial Intelligence in Materials Science and Engineering. [PDF]
Lacki P +4 more
europepmc +1 more source

