Results 141 to 150 of about 12,414 (350)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Numerical and computational investigation of soliton propagation in physical systems via computational schemes: (1+1)-dimensional MNW integrable equation

, 2023
Tianyong Han, Mostafa M. A. Khater
openalex   +1 more source

Energy-Entropy-Momentum integration of discrete thermo-visco-elastic dynamics.

, 2011
A novel time integration scheme is presented for the numerical solution of the dynamics of discrete systems consisting of point masses and thermo-visco-elastic springs.
García Orden, Juan Carlos, Romero Olleros, Ignacio   +1 more
core  

Numerical Energy Conservation for Multi-Frequency Oscillatory Differential Equations

, 2005
The long-time near-conservation of the total and oscillatory energies of numerical integrators for Hamiltonian systems with highly oscillatory solutions is studied in this paper.
D. Cohen, E. Hairer, Cohen, David, Lubich, Christian, Hairer, Ernst,, Lubich, Christian,, Ch. Lubich, Hairer, Ernst, Cohen, David,   +8 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Numerical integration of the rate equations of the MerB reaction mechanism

, 2015
Pedro Silva
openalex   +1 more source

A new approach to numerical integration based on Coifman wavelets [PDF]

, 2019
Bachir Dehda
openalex   +1 more source

Approximate Exponential Integrators for Time-Dependent Equation-of-Motion Coupled Cluster Theory. [PDF]

J Chem Theory Comput, 2023
Williams-Young DB, Yuwono SH, DePrince Iii AE, Yang C.   +3 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Phasewise numerical integration of finite element method applied to solidification processes

, 2000
Norberto M. Nigro, Alfredo E. Huespe, Vı́ctor D. Fachinotti   +2 more
openalex   +2 more sources