Results 131 to 140 of about 12,414 (350)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Numerical Integrators That Preserve Symmetries and Reversing Symmetries

, 1996
We consider properties of flows, the relationships between them, and whether numerical integrators can be made to preserve these properties. This is done in the context of automorphisms and antiautomorphisms of a certain group generated by maps ...
G. R. W. Quispel, G. S. Turner, Robert I. Mclachlan   +2 more
core  

Properties of Hamiltonian Variational Integrators [PDF]

, 2017
This dissertation explores Hamiltonian variational integrators. Variational integrators are a common class of symplectic integrators, which have primarily been analyzed and constructed by discretizing Hamilton's principle.
Schmitt, Jeremy M.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Towards Robust Variational Quantum Simulation of Lindblad Dynamics via Stochastic Magnus Expansion

PRX Quantum
Dedicated to the centenary of quantum mechanics. In this paper, we introduce a novel and general framework for the variational quantum simulation of Lindblad equations.
Jia-Cheng Huang, Hao-En Li, Yi-Cheng Wang, Guang-Ze Zhang, Jun Li, Han-Shi Hu   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Quantifying Diapir Ascent Velocities in Power‐Law Viscous Rock Under Far‐Field Stress: Integrating Analytical Estimates, 3D Numerical Calculations and Geodynamic Applications [PDF]

, 2023
Emilie Macherel, Yury Podladchikov, Ludovic Räss, Stefan M. Schmalholz   +3 more
openalex   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Fast Multilevel Dimension Iteration Algorithm for High Dimensional Numerical Integration [PDF]

, 2023
Xiaobing Feng, HUICONG ZHONG
openalex   +1 more source

Preserving Multiple Conserved Quantities of Stochastic Differential Equations via Projection Technique

Mathematics
Stochastic differential equations (SDEs) with multiple conserved quantities are ubiquitous in scientific fields, modeling systems from molecular dynamics to celestial mechanics.
Xuliang Li, Zhenyu Wang, Xiaohua Ding
doaj   +1 more source