Results 111 to 120 of about 12,414 (350)

Long-term analysis of numerical integrators for oscillatory Hamiltonian systems under minimal non-resonance conditions

, 2015
For trigonometric and modified trigonometric integrators applied to oscillatory Hamiltonian differential equations with one or several constant high frequencies, near-conservation of the total and oscillatory energies are shown over time scales that ...
Cohen, David, Lubich, Christian, Gauckler, Ludwig,, Hairer, Ernst,, Lubich, Christian,, Gauckler, Ludwig, Hairer, Ernst, Cohen, David,   +7 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Lie groups and continuum mechanics: where do we stand today?

Comptes Rendus. Mécanique
The geometric methods have experienced a fast growth in the past few decades. In this survey, we discuss the use of Lie groups in continuum mechanics. We address both the theoretical and numerical aspects.
de Saxcé, Géry, Razafindralandy, Dina
doaj   +1 more source

Integrator Sensitivity of Chaos in the Ultradian Glucose-Insulin Model [PDF]

EPJ Web of Conferences
Diabetes mellitus is a long-term metabolic disorder. It happens when the glucose-insulin system does not work properly. As a result, blood glucose levels are not well controlled. The ultradian model helps describe the main processes of this system.
Sinha Aitijhya, Chowdhury Sourav, Roychowdhury Suparna   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Numerical Integration

, 2012
Rectangles, Trapezoids, and Simpson's I just wrapped up a semester of calculus TA duties, and I thought it would be fun to revisit the problem of integration from a numerical standpoint.
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A novel alternative to numerical integration [PDF]

, 2017
N. Mohankumar, Soubhadra Sen, A. Natarajan   +2 more
openalex   +1 more source

Error Analysis on Numerical Integration Algorithms in a Hypoelasticity Framework

, 2021
Miklos Zoller
openalex   +2 more sources