Results 91 to 100 of about 12,414 (350)

A Quantitative Approach to Universal Numerical Integrators (UNIS) with Computational Application

Human-Centric Intelligent Systems
In this paper, we examine the mathematics that makes it possible to couple a conventional numerical integrator (e.g., Euler, Runge-Kutta, among others) with some universal approximator of functions (e.g., artificial neural networks, fuzzy inference ...
Paulo M. Tasinaffo, Luiz A. V. Dias, Adilson M. da Cunha   +2 more
doaj   +1 more source

Research on knowledge-sharing decisions in the logistics service supply chain

Frontiers in Physics
PurposeThis study investigates the knowledge-sharing decision-making mechanisms in logistics service supply chains (LSSCs), focusing on the strategic interactions between logistics service integrators and providers.Design/methodology/approachThe study ...
Guanbing Zhao, Guanbing Zhao, Jiamiao Zheng, Kuijian Zhan   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Numerical solution of two‐dimensional nonlinear Riesz space‐fractional reaction–advection–diffusion equation using fast compact implicit integration factor method [PDF]

, 2023
Chetna Biswas, Subir Das, Anup Singh, Tomasz Sadowski   +3 more
openalex   +1 more source

A class of implicit symmetric symplectic and exponentially fitted Runge–Kutta–Nyström methods for solving oscillatory problems

Advances in Difference Equations, 2018
The construction of implicit Runge–Kutta–Nyström (RKN) method is considered in this paper. Based on the symmetric, symplectic, and exponentially fitted conditions, a class of implicit RKN integrators is obtained.
Huai Yuan Zhai, Wen Juan Zhai, Bing Zhen Chen   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Genetic algorithm for design optimization of multibody dynamics using differential–algebraic equation integrators

Advances in Mechanical Engineering, 2015
Based on the general model of design optimization of multibody dynamics, a modified genetic algorithm with adaptive crossover and mutation rates is developed to find optimal design variables which satisfy the dynamic constraints and obtain optimum ...
Jieyu Ding
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Solving oscillatory problems using a block hybrid trigonometrically fitted method with two off-step points

Electronic Journal of Differential Equations, 2013
A continuous hybrid method using trigonometric basis (CHMTB) with two "off-step" points is developed and used to produce three discrete hybrid methods which are simultaneously applied as numerical integrators by assembling them into a block hybrid ...
Fidele F. Ngwane, Samuel N. Jator
doaj  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source