Results 201 to 210 of about 12,414 (350)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Implicit-explicit time integration algorithms for the numerical simulation of blade/casing interactions

, 2002
Ludovic Noels, Laurent Stainier, Jean‐Philippe Ponthot, Jérôme Bonini   +3 more
openalex   +2 more sources

Gpu-accelerated JEMRIS for extensive MRI simulations. [PDF]

MAGMA
Nurdinova A, Ruschke S, Gestrich M, Stelter J, Karampinos DC.   +4 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Two-step Explicit Methods for the Numerical Integration of a System of Second Order Initial Value Problems

, 2016
Periodic initialx Periodic initial value problem, Stability properties   +1 more
openalex   +1 more source

Stability analysis and numerical simulation of nonlocal extended epidemic models using positivity-preserving scheme. [PDF]

Sci Rep
Yousuf M, Alshakhoury N.
europepmc   +1 more source

Numerical stability of force-gradient integrators and their Hessian-free variants in lattice QCD simulations

We investigate the numerical stability of force-gradient integrators and their Hessian-free variants within the molecular dynamics step of the Hamiltonian Monte Carlo algorithm in lattice QCD simulations.
Schäfers, Kevin, Finkenrath, Jacob, Günther, Michael, Knechtli, Francesco   +3 more
core  

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

The development of a PC based software to solve M/M/1 and M/M/S queueing systems by using a numerical integration technique

, 1994
Jinchun Ho
openalex   +1 more source

Supplementary material to "An adaptive method for speeding up the numerical integration of chemical mechanisms in atmospheric chemistry models: application to GEOS-Chem version 12.0.0"

, 2019
Lu Shen, Daniel J. Jacob, Mauricio Santillana, Xuan Wang, Wei Chen   +4 more
openalex   +1 more source