Results 61 to 70 of about 3,849,710 (299)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Numerical inverse transformation for map projections

Computers & Geosciences, 2003
In cartography map projections are used to transform geographical coordinates to plane coordinates. This is called forward transformation. For many geographic information system (GIS) applications paper maps are digitised, and so captured data are integrated into another data set.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Computational Approach for Differential Equations with Local and Nonlocal Fractional-Order Differential Operators

Journal of Mathematics, 2023
Laplace transform has been used for solving differential equations of fractional order either PDEs or ODEs. However, using the Laplace transform sometimes leads to solutions in Laplace space that are not readily invertible to the real domain by ...
null Kamran, Ujala Gul, Fahad M. Alotaibi, Kamal Shah, Thabet Abdeljawad   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Evolution law of dominant flow channel of water flooding in partially enclosed fault reservoir

Youqi dizhi yu caishoulu
A partially enclosed fault reservoir is a common reservoir type. The partially enclosed faults caused by low-order faults lead to different fluid flow and distribution laws of remaining oil between partially enclosed fault reservoirs and completely ...
CAO Xiaopeng, YU Chunlei, ZHAO Wenjing, ZHANG Min   +3 more
doaj   +1 more source

Inverse Kinematics of a Serial Robot

MATEC Web of Conferences, 2016
This work describes a technique to treat the inverse kinematics of a serial manipulator. The inverse kinematics is obtained through the numerical inversion of the Jacobian matrix, that represents the equation of motion of the manipulator.
Amici Cinzia, Cappellini Valter
doaj   +1 more source

A graph-theoretic approach to sparse matrix inversion for implicit differential algebraic equations [PDF]

Mechanical Sciences, 2013
In this paper, we propose an efficient numerical scheme to compute sparse matrix inversions for Implicit Differential Algebraic Equations of large-scale nonlinear mechanical systems.
H. Yoshimura
doaj   +1 more source