Results 31 to 40 of about 13,821 (242)
, 2020 Recent clinical trials have shown that adaptive drug therapies can be more efficient than a standard cancer treatment based on a continuous use of Maximum Tolerated Doses (MTD). The adaptive therapy paradigm is not based on a preset schedule; instead, the doses are administered based on the current state of tumour.
Gluzman, Mark +2 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Simulation of Physical, Chemical, and Biochemical Environmental Processes with Spreadsheets and VBA
Spreadsheets in Education, 2021 Dynamic simulation of physical, chemical, and biochemical reactions is usually difficult for environmental engineering students since most of water and wastewater treatment systems rely on several combinations of these reactions.
Selami Demir
doaj
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Levenberg-Marquardt Method for the Eigenvalue Complementarity Problem
The Scientific World Journal, 2014 The eigenvalue complementarity problem (EiCP) is a kind of very useful model, which is widely used in the study of many problems in mechanics, engineering, and economics.
Yuan-yuan Chen, Yan Gao
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Ìнформаційні технології в освіті, 2018 The article discusses the possibilities of using the integrated Word and Matlab environment for training students of the physics and mathematical profile of computing methods.
Doroshenko M.
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Numerical Methods for Mathematical Programs with Disjunctive Constraints
, 2016 Motiviert durch steigendes Interesse an mathematischen Programmen mit komplementaren Nebenbedingungen (en. MPCCs) und mathematischen Programmen mit verschwindenden Nebenbedingungen (en. MPVCs) beschaftigen wir uns in dieser Arbeit mit einer Verallgemeinerung dieser Programme - sogenannte mathematische Programme mit disjunktiven Nebenbedingungen (en ...
openaire +2 more sources